多杀性巴氏杆菌脂多糖的结构与功能研究进展

doi:doi: 10.11843/j.issn.0366-6964.2016.10.003

Abstract

Abstract:

Pasteurella multocida (P.multocida)，a Gram-negative cocco-bacillus，facultative anaerobic bacterium，is the causative agent of serious diseases in a wide range of animals.Lipopolysaccharide (LPS) is an important virulence factor，and is also a major immune protective antigen of P.multocida which is currently classified into 16 Heddleston serovars based on LPS.Unlike the other Gram-negative pathogens，P.multocida LPS is only made up of lipid A and core oligosaccharide，lacking an O-antigen.Recently，chemical structures and biosynthesis genes of 16 Heddleston serovars LPS have been determined by using mass spectrometry and gene sequencing.The inner core structures are highly conserved among different serovars，and genes required for the assembly of the inner core are located in several regions of the genome.In contrast，the outer core structures are distinct，and genes required for the biosythesis of the outer core structures are clustered in a single locus between the conserved genes priA and fpg.Some LPS serovars genetically have relationship each other，sharing the same outer core biosythesis locus，but producing different LPS molecules due to mutations within glycosyltransferase genes.Furthermore，LPS structures of P.multocida are related to bacterial virulence.Here，we summarize LPS structures，biosythesis genes and the relationships between LPS and bacterial virulence in P.multocida.

CLC Number:

R378.6

HUA Rui-qi，ZHAO Xin-xin，CHENG An-chun. Research Progress in the Lipopolysaccharide of Pasteurella multocida[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(10): 1961-1968.

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Research Progress in the Lipopolysaccharide of Pasteurella multocida

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