Screening Candidate Differentially Expressed Genes of Rex Rabbits’ Fur Color with Gene Chips
SHI Li-juan1，2，QIN Li-zhi1，2，WANG Wen-zhou1，2，YAN Xiao-rong1，2，WENG Qiao-qing3，WU Xin-sheng1，2*
(1.College of Animal Science and Technology，Yangzhou University，Yangzhou 225009，China；2.Jiangsu Key Laboratory of Animal Genetics & Breeding and Molecular Design，Yangzhou 225009，China；3.Zhejiang Yuyao Xinnong Rabbit Industry Co.，Ltd.，Yuyao 315400，China)
SHI Li-juan，QIN Li-zhi，WANG Wen-zhou，YAN Xiao-rong，WENG Qiao-qing，WU Xin-sheng. Screening Candidate Differentially Expressed Genes of Rex Rabbits’ Fur Color with Gene Chips[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(4): 568-575.
［1］MARIE M，VERA S D，RICARDO M，et al.The developmental role of agouti in color pattern evolution ［J］.Science，2011，331(25)：1062-1065.
［2］STURM R A.Molecular genetics of human pigmentation diversity［J］.Hum Mol Genet，2009，18(1)：9-17.
［3］TEASDELE R D，STURM R A，BOX N F.Human pigmentation genes：Identification，structure and consequences of polymorphic variation［J］.Gene，2001，277：49-62.
［4］BENNETT D C，LAMOREUX M L.The color loci of mice-a genetic century［C］.Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society，2003，16(4)：333-344.
［5］CONE R D，LU D，KOPPULA S，et al.The melanocortin receptors：agonists，antagonists，and the hormonal control of pigmentation［J］.Recent Prog Horm Res，1996，51：287-317，318.
［6］HARTMEYER M，SCHOLZEN T，BECHER E，et al.Human dermal microvascular endothelial cells express the melanocortin receptor type 1 and produce increased levels of IL-8 upon stimulation with alpha-melanocyte-stimulating hormone［J］.J Immunol，1997，15(4)：1930-1937.
［7］高文玉．关于家兔毛色遗传规律的探讨分析［J］．中国农学通报，2012，28（8）：19-23．
GAO W Y.Study and analysis on the genetic regulation of rabbit hair color［J］. Chinese Agricultural Science Bulletin，2012，28(8)：19-23.(in Chinese)
［8］KIJAS J M H，WALES R，TORNSTEN A，et al.Melanocortin receptor 1 (MC1R) mutations and coat color in pigs［J］.Genetics，1998，150：1177-1185.
［9］BAUER G L，PRAETORIUS C，BERGSLEINSDOTTIR K，et al.The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue［J］.Genetics，2009，183(2)：581-594.
［10］MARKLUND S，MOLLER M，SANDBERG K，et al.Close association between sequence polymorphism in the KIT gene and the roan coat color in horses［J］.Mamm Genome，1999，10(3)：283-288.
［11］MUNDY N I，KELLY J.Investigation of the role of the agouti signaling protein gene (ASIP) in coat color evolution in primates［J］.Mamm Genome，2006，17(12)：1205-1213.
［12］PHILIPP U，HAMANN H，MECKLENBURG L，et al.Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs［J］.BMC Genet，2005，6：34.
［13］BRUNBERG E，ANDERSSON L，COTHRAN G，et al.A missense mutation in PMEL17 is associated with the Silver coat color in the horse［J］.BMC Genet，2006，7：46.
［14］FODOR S P A，READ J L，PIRRUN G M C.Light directed spatially addressable parallel chemical synthesis［J］.Science，1991，251：767-773.
［15］CHEN C P，CHIANG M C，WANG T H，et al.Microvillus inclusion disease：prenatal ultrasound findings，molecular diagnosis and genetic counseling of congenital diarrhea［J］.Taiwan J Obstet Gyne，2010，49(4)：487-494.
［16］安利峰，胜利．基因芯片及其应用进展［J］．西北民族学院学报，2002，23（2）：40-42．
AN L F，SHENG L.Gene core and its application progress［J］.Journal of Northwest Minorities University，2002，23(2)：40-42.(in Chinese)
［17］POLATI R，MENINI M，ROBOTTI E，et al.Proteomic changes involved in tenderization of bovine longissimus dorsi muscle during prolonged ageing［J］.Food Chem，2012，135(3)：2052-2069.
［18］杨静，冯家成，孟晓，等．基因表达谱芯片在预测子宫颈上皮内瘤变进展风险中应用［J］．临床与实验病理学杂志，2013，29（1）：53-57．
YANG J，FENG J C，MENG X，et al.The role of gene expression profile chip in the prediction of cervical intraepithelial neoplasia to cervical cancer［J］.Chinese Journal of Clinical and Experimental Pathology，2013，29(1)：53-57.(in Chinese)
［19］李挺．利用表达谱芯片技术筛选獭兔肌肉发育相关基因［D］．扬州：扬州大学，2013．
LI T.Screening genes for muscle of rabbit by cDNA microarray［D］.Yangzhou：Yangzhou University，2013.(in Chinese)
［20］LEVITT M，SPECTOR S，SJOERDSMA A，et al.Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused guinea-pig heart［J］.J Pharmacol Exp Ther，1965，148：1-8.
［21］韩宇，刘春，魏丽婉，等．家蚕酪氨酸羟化酶基因BmTh的表达及功能［J］．昆虫学报，2010，53（9）：949-956.
HAN Y，LIU C，WEI L W，et al.Expression profile and function of tyrosine hydroxylase gene BmTh in the silkworm［J］.Acta Entomologica Sinica，2010，53(9)：949-956.(in Chinese)
［22］卜今．丹皮酚抑制黑素合成相关分子机制的研究及KC-MC共培养体系中细胞因子对黑素合成的反馈调节［D］．北京：北京协和医院，2008．
PU J.A study on the molecular mechanism of inhibition on melanogenesis induced by paeonol and the feedback regulation on melanin synthesis by cytokines in KC-MC co-culture system［D］.Beijing：Peking Union Medical Hospital，2008.(in Chinese)
［23］PRICE E R，HORSTMANN M A，WELLS A G，et al.Fisher DE alpha-melanocyte-stimulating hormone signaling regulates expression of microphthalmia，a gene deficient in Waardenburg syndrome［J］.J Biol Chem， 1998，273：33042-33047.
［24］DIJKSTERHUIS J P，PETERSEN J，SCHULTE G.WNT/Frizzled signalling：receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance：IUPHAR review 3［J］.Br J Pharmacol，2014，171(5)：1195-1209.
［25］BOLAND G M，PERKINS G，HALL D J，et al.Wnt 3 apromotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cell［J］.Cell Biochem，2004，93(6)：1210-1230.
［26］于秀菊，董常生，范阔海，等．β-catenin在不同毛色羊驼皮肤中的表达和定位［J］．畜牧兽医学报，2010，41（3）：335-340．
YU X J，DONG C S，FAN K H，et al.Study on the expression and localization of β-catenin in alpaca skin of different colors［J］.Acta Veterinaria et Zootechnica Sinica，2010，41(3)：335-340.(in Chinese)
［27］PHAM K，MILOVANOVIC T，BARR R J，et al.Wnt ligand expression in malignant melanoma：pilot study indicating correlation with histopathological features［J］.Mol Pathol，2003，56(5)：280-285.
［28］DAVIES M A，GERSHENWALD J E.Targeted therapy for melanoma：a primer ［J］.Surg Oncol Clin N Am，2011，20(1)：165-180.
［29］VAN RAAMSDONK C D，FITCH KR，FUCHS H，et al.Effects of G-protein mutations on skin color［J］.Nat Genet，2004，36：961-968.
［30］VAN RAAMSDONK C D，BEZROOKOVE V，GREEN G，et al.Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi［J］.Nature，2009，457(7229)：599-602.
