ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2016, Vol. 47 ›› Issue (6): 1086-1092.doi: 10.11843/j.issn.0366-6964.2016.06.002

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Research Progress of the Role of microRNAs in the Regulation of Animal Coat and Skin Color

WU Xiao-qian,LIU Chen-dong,DU Jing-jing,LUO Jia,ZHU Li* ,ZHANG Shun-hua*   

  1. (College of Animal Science and Technology,Sichuan Agricultural University,Chengdu 611130,China)
  • Received:2015-12-22 Online:2016-06-23 Published:2016-06-23

Abstract:

Melanocyte,generated from embryonic neural crest stem cells,plays important roles in coat and skin color formation.Melanin,the product of a series of enzyme catalyzed reactions in melanocyte,determines animal coat and skin color.Melanogenesis is a complex process involving coordinated regulation of some transcription factors,hormones and signaling pathway molecules.microRNA (miRNA) is a class of endogenous,non-coding,small RNA molecule (about 22 nt),which regulates gene expression mainly at the post-transcription level.More and more evidences demonstrated that miRNA involve in the regulation of melanogenesis.Herein,it was reviewed in this paper the studies on the discovery and identification of melanin-associated miRNAs,and the research progress of how miRNAs regulate animal coat and skin color.

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