ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2012, Vol. 43 ›› Issue (9): 1337-1345.doi:

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Research Progress on Vaccines of Porcine Circovirus Type 2

WANG Yi-ping, GUO Long-jun, TANG Qing-hai, LIU Chang-ming*   

  1. (Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology,
    Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences,
    Harbin 150001, China)
  • Received:2012-04-05 Online:2012-09-25 Published:2012-09-25

Abstract: Porcine circovirus type 2 (PCV2) has been recognized as the primary causative agent of postweaning multisystemic wasting syndrome (PMWS), which results in tremendous economic losses in swine industry worldwide. PCV2 infection leads to impaired immune system in animals, severe immunosuppression, as well as co-infection and secondary infection among various bacteria and viruses, which will bring about tremendous obstacles in diagnosis and therapy. It is an effective way to control PCV2 infection by vaccination. The study on PCV2 vaccines is one of the hot research areas. To date, the inactivated vaccines of PCV2, subunit vaccines and chimeric virus vaccines are commercially available in North America and Europe, and the inactivated vaccines of PCV2 have also been developed in China. Development and application of the commercial PCV2 vaccines play a significant role in the prevention and control of PCV2 associated diseases effectively. However, the commercial PCV2 vaccines could not totally block the transmission of PCV2 among pigs and eliminate the virus in pigs. Therefore, it is the main research trend to develop efficient and inexpensive genetically engineered vaccines such as live vector vaccines, DNA vaccines and marker vaccines in the future. This article summarizes the characteristics and efficacy of currently commercial PCV2 vaccines, and reviews the recent achievements on PCV2 vaccines including live vector vaccines, DNA vaccines and marker vaccines. It may become a useful contributor to the next generation vaccines for control of PCV2-associated diseases.

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