Abstract: In order to observe the histopathological changes of the rabbits infected with Cysticercus pisiformis, tissues of livers, hearts, kidneys and lungs from 33 naturally infected rabbits were collected. All the samples were fixed in the formalin and dehydrated with gradient alcohol. The 5-6 μm paraffin sections were made and stained with haematoxyylin and eosin, then were obser ved by light microscope. The results showed that zones of hemorrhaged necrosis caused by the migration of oncospheres of Taenia Pisiformis was formed on the surface of the rabbits livers, as well as a granulation tumor consisted of epithelioid cell and multiple nuclear giant cell. This special pathological change could be one of the important diagnosis points of the disease. Meanwhile, other pathological changes such as interstitial hepatitis, brightism, pneumonia and heart muscle fiber atrophy were also observed. This study layed the foundation for the elucidation of the characteristic pathological change of liver and the development mechanism of this disease.