Abstract: This study was conducted to analyze genetic effect of FUT1 gene M307 on some immune parameters in foundation population of Sutai ETEC F18 resistant breeding pigs and aimed to provide a theoretical foundation for further anti-disease breeding of Sutai pigs. The genetic variations at M307 of FUT1 gene in foundation population of Sutai ETEC F18 resistant breeding pigs (total 576 individuals) were investigated by PCR-RFLP method. The relationship between FUT1 gene and some immune parameters were analyzed in this study. The results showed that M307 of FUT1 gene digested by Hin6Ⅰcould be divided into three kinds of genotypes, AA, AG and GG. The genotype frequencies of AA, AG and GG at FUT1 locus were 0.235, 0.609 and 0.156, respectively. The allele A was dominant allele, its frequency was 0.540. This locus deviates from Hardy-Weinberg equilibrium (P<0.01) in above foundation population. The individuals with resistant genotype AA were significantly higher than those individuals with AG and GG genotypes（P<0.05）in HGB and WTBC, while there were no significant difference between AG and GG genotypes (P>0.05). The individuals with resistant genotype AA were significantly lower than those individuals with AG and GG genotypes（P<0.05）in heterophil/lymphocyte(H/L) ratio, while there were no significant difference between AG and GG genotypes (P>0.05). For SRBC antibody titer, there were no significant difference among AA, AG and GG genotypes (P>0.05). These results demonstrated that the resistant populations to ETEC F18 with genotype AA also showed fine characters of stress resistance，AA genotype had good genetic effects on disease resistance traits of PWD and ED, as well as normal disease resistance.