ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2010, Vol. 41 ›› Issue (10): 1317-1321.doi:

• 基础兽医 • Previous Articles     Next Articles

Bioavailability of Marbofloxacin in Dogs by Oral Administrate

LIU Li-feng, GAO Li-li, SU Feng, JIANG Shan-xiang*   

  1. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-10-25 Published:2010-10-25

Abstract: This experiment was conducted to investigate the pharmacokinetics and bioavailability of marbofloxacin in healthy dogs. A single oral or i.v. administration of the drug at the dose of 2.75 mg·kg-1 to 8 dogs were performed in an open randomized crossover test. Blood samples were collected at different intervals after administration and concentrations of marbofloxacin were determined by HPLC method. The concentrationtime date were analyzed with 3P97 computer program to get the pharmacokinetics parameters.The drug concentration-time data were fitted to a no absorbed two-compartment open model after i.v. administration in pigs. The main pharmacokinetic parameters were as follows T1/2α(0.34±0.14)h,T1/2β (7.74±1.70)h,V(1.03±0.60)L·kg-1, CL(0.22±0.08)L·h-1; AUC(14.05±4.25)mg·mL-1·h. The drug concentration-time data were fitted to a two-compartment model with first order absorption after single oral administration in dogs. The main pharmacokinectic parameters were as follows: T1/2α((2.82±1.86)h, T1/2β(16.03±9.27)h, V/F(2.25±0.34)L·kg-1,CL/F(0.21±0.05)L·h-1,Tmax(1.55±0.62)h,Cmax(0.89±0.21)μg·mL-1,AUC(13.66±2.77)mg·mL-1·h. Marbofloxacin was rapidly absorbed and the drug was completely absorbed after single oral administration and have a good bioavailability in dogs.