Abstract: In order to study the effects of Chaiqikeli (CQKL) on liver protection, antibacterial action and immunity function, hepatic injury models were established by injecting carbon tetrachloride (CCl₄)and D-galactosamine (D-GalN)into mouse and then the different dose of CQKL were given respectively. The activity of ALT and AST in the serum, the contents of glutathione (GSH) in liver homogenate from all mouse were determined. It is suggested that CQKL could significantly protect liver from CCl₄ and D-GalN injury, lower the activity of enzyme ALT, AST in serum, shorten the sleep duration induced by embuter in CCl₄ damaged mice,improve the phagocytic function of reticuloendothelial system in mice and inhibit bacterial in vitro. CQKL have the antibacterial,liver protection and immunological enhancement effects.