Abstract: In F₁ individuals of Large White × Meishan, weight of 180 days, ratio of feedstuff to meat, average daily gain and days for 90 kg living weight were tested, and relative growth ratio and Kleiber ratio were calculated. The relationship between DNA methyaltion and these growth traits were analyzed with methylation-sensitive amplified polymorphism (MSAP) technique. In all, 1 274 sites were amplified with 81 methylated sites significant effected on growth traits in 252 polymorphic sites (P＜0.05). The number of overall cytosine sites between parental lines and hybrid F₁ were not singnificantly different, but the number of methylation sites amplified by each pair primers was significantly different(P＜0.05). Results show that general and neutral individual methylation percentage differences didn’t significantly effect on performance of any growth traits, but special individual methylation percentage difference significantly effected on performance of Kleiber ratio, ratio of feedstuff to meat, average daily gain and days for 90 kg. Performances of the 5 growth traits all decreased as special individual methylation percentage difference (SIMPD) increased in view of improving pig productivity. The linear regression between SIMPD and values of 5 growth traits were significant. It can be concluded that DNA methylation can effects hybrid performance or heterosis and be used as DNA markes in predicting heterosis and related studies of pigs; methylated sites that significantly effect on a trait are superior to other methylated sites in predicting hybrid performance.