ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2011, Vol. 42 ›› Issue (2): 272-277.doi:

• 基础兽医 • Previous Articles     Next Articles

The Relationship Between Liver Injury and Hydrogen Sulfide in Endotoxemiaand Analysis of Protection of Cation A

CHEN Chao1,2，GAO Hong1，YAN Yu-lin1*，CHEN Li-ping1，GAO Li-bo1，ZHAO Ru1，CHEN Ling1   

  1. 1. College of Animal Science and Technology, Yunnan Agriculturl University, Kunming 650201,China；2. Kunming Police Dog Base of Ministry of Public Security, Kunming 650204, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2011-02-25 Published:2011-02-25

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Abstract: To explore the realationship between liver injury and hydrogen sulfide (H2S) in endotoxemia and protection of Cation A (CA) in rats. Seventy-two adult healthy SD rats were randomly divided into three groups: control group, ET group, CA group. Hepatic tissue and blood serum of three groups were collected for tests at the 3rd, 4th, 8th and 12th hour after treatment The concentration of ALT and AST in serum were detected. The production rate of H2S in liver were measured by spectrophotography. The transcriptional level of CSE mRNA were investigated by in situ hybridization and by image analysis. Compared with control group, ALT and AST level in serum of ET group were significantly higher. In CA group, ALT and AST level is significantly lower than that of ET group. The production rate of H2S in liver of ET group were significantly higher than that of control group, while these items in CA group were significantly lower compared with ET group. The transcriptional level of CSE mRNA and the production rate of H2S in liver were significantly up-regulated and the up-regulation were inhibited markedly by CA. These above results suggested the novel gaseous transmitter H2S mediate liver injure in endotoxemia, whereas CA have a significantly pretective effect on inflammatory injure through down-regulation of the CSE/H2S pathway in liver.