Abstract: The aim of this study was to detect the relationships between the genotypes of IL-8R and Lactoferrin genes and subclinical mastitics. The genotypes of IL8R and Lactoferrin genes of 80 healthy and 80 subclinical mastitics-dairy cows were detected by using PCRSSCP technique, and the relationships with the number of somatic cells in the milk were analysed. The results showed that the frequencies of genotype SSCP-5 and SSCP-7 of IL-8R CXCR1 were high in the healthy dairy cows and indicated that individuals with genotype AB performed resistance to subclinical-mastitics.