ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2007, Vol. 38 ›› Issue (10): 1060-1065.doi:

• 动物营养 • Previous Articles     Next Articles

Effect of EPA and DHA on Lymphocyte Proliferation and Intracellular Signaling Molecules in Weanling Pigs

Effect of EPA and DHA on Lymphocyte Proliferation and Intracellular
Signaling Molecules in Weanling Pigs   

  1. 1 National Feed Engineering Technology Research Center, China Agricultural University, Beijing 100094, China; 2State Key Laboratory of Animal Nutrition, Beijing 100094, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-10-25 Published:2007-10-25

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Abstract: The experiment was conducted to investigate the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on peripheral blood lymphocyte proliferation and intracellular signaling molecules in weanling pigs. The results showed that EPA and DHA inhibited lymphocyte proliferation (P < 0.05) and stimulated nitric oxide (NO) (P < 0.001), cAMP (P < 0.001) and cGMP (P < 0.001) production and cAMP/ cGMP ratio in a dose-dependent manner. EPA and DHA induced a momentary rise of intracellular Ca2+, and the rising extent was dependent on the concentration of EPA and DHA. EPA and DHA also inhibited protein kinase C activity in a dose-dependent manner (P < 0.05), and had no effect on protein kinase A activity. These results suggested that EPA and DHA exert an inhibitory effect on lymphocyte function, possibly due to alteration of intracellular signal transduction.