ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2007, Vol. 38 ›› Issue (9): 920-925.doi:

• 遗传繁育 • Previous Articles     Next Articles

β-cypermethrin Regulating the Testosterone Synthesis of Male Mouse through ERK1/2 Cascade

WANG Xian-zhong;WU Jian-yun;SUN Yan;LUO Ying;LI Guan-hua;YUAN Zun-xue; WANG Xi-ming;ZHANG Jia-hua   

  1. 1. Chongqing Key Laboratory of Forage & Herbivorce,College of Animal Science, Veterinary and Aquaculture, Southwest University，Chongqing 400716, China；2.Chongqing Animal Health Supervision General Station, Chongqing 400000,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-09-25 Published:2007-09-25

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Abstract: To study the effects of β-cypermethrin on the testosterone synthesis. Matured kunbai mouse were fed different concerntration of β-cypermethrin for 7 days RT-PCR, Western blot and radioimmunoassay(RIA) were used to analyze the ability of testosterone synthesis.The results were as followed: with the increase of β-cypermethrin concerntration,the weight of testis, the expression of P450scc mRNA ,3β-HSD mRNA and StAR mRNA had no difference between different groups.However, the expression of P450c17 mRNA and the level of StAR protein decreased significantly and the activity of ERK1/2 increased significantly. These results inferred that β- cypermethrine could inhibit the synthesis of testosterone through increasing the activity of ERK1/2 to decrease the activity of P450c17 mRNA and level of StAR Protein