ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2014, Vol. 45 ›› Issue (6): 1018-1023.doi: 10.11843/j.issn.0366-6964.2014.06.022

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Preparation and Analysis of Albendazole Solid Dispersions

DONG Chun-liu,LIU Yan-yan,WANG Tian-zi,TONG Heng-min,LI Yan-hua*   

  1. (Department of Animal Pharmacy,College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China)
  • Received:2013-10-29 Online:2014-06-23 Published:2014-06-23

Abstract:

Solid dispersions of albendazole were prepared by melt technique using polyethylene glycol 6000 (PEG6000) and poloxamer 188 (P188) in combination (1∶2).When the ratio of albendazole (ABZ) and combined carrier was 1∶5,the dissolution characteristics of solid dispersion were evaluated through measuring the phase solubility studies and dissolution studies.The solid dispersion was investigated using X-ray diffraction analysis,Fourier-transform infrared spectroscopy and scanning electron microscopy.The results showed that PEG6000 and P188 were recognised as a better combined carrier when preparing solid dispersion of albendazole,and can significantly improve the in vitro dissolution rate to 90.48%.No chemical interaction was found between ABZ and combined carrier,and solid dispersion pattern is amorphous shape.These results indicated that as a combined carrier,the proper ratio of elected PEG6000 to P188 was 1 to 2,and preparation by melt technique for solid dispersion can significantly improve the dissolution of ABZ,and the preparation is simple.

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