热休克蛋白在冷应激引起的炎症反应和氧化应激中的调节作用

doi:10.11843/j.issn.0366-6964.2022.06.002

摘要/Abstract

摘要： 冬季持续低温引起的冷应激是降低北方畜牧业经济效益和动物福利的重要因素，可诱导动物产生炎症反应和氧化应激危害机体健康。热休克蛋白作为体内重要的分子伴侣蛋白，在维持机体内环境稳态、帮助动物抵抗应激方面有重要作用，低温环境可激活热休克蛋白快速产生，以此在细胞内外对免疫和抗氧化系统发挥重要调节作用：在胞外，具有保护细胞、参与调节免疫细胞功能、激发免疫反应和提高抗氧化酶活性等作用；在胞内，可抑制NF-κB信号通路保护机体免受炎症损伤，上调Nrf2信号通路提高机体抗氧化功能，缓解冷应激对机体造成的负面影响。本文总结了国内外关于在冷应激状态下热休克蛋白对机体免疫和抗氧化功能的调节作用及其机制，并给出部分提高热休克蛋白表达水平的方法，以期为后续畜禽的冷应激理论研究提供参考。

关键词: 冷应激, 热休克蛋白, 免疫调节, 抗氧化功能

Abstract: Cold stress caused by continuous low temperature in winter is an important factor that reduces the economic benefits and animal welfare of northern animal husbandry, and can induce animal inflammation and oxidative stress to endanger the health of the organism.As an important molecular chaperone protein in the organism, heat shock protein plays an important role in maintaining the homeostasis of the organism's environment and helping animals resist stress. The low temperature environment can activate the rapid production of heat shock proteins, which can play an important role in regulating the immune and antioxidant systems inside and outside the cell: outside the cell, it has the functions of protecting cells, participating in regulating immune cell functions, stimulate immune response, and improve anti-oxidation enzyme activity; inside the cell, it can inhibit the NF-κB signaling pathway to protect the organism from inflammatory damage, up-regulate the Nrf2 signaling pathway to improve the organism's antioxidant function, and alleviate the negative effects of cold stress on the organism. This article summarizes the regulatory effects and mechanisms of heat shock proteins on the immune and antioxidant functions of the organism under cold stress conditions at home and abroad and gives some methods to increase the expression level of heat shock proteins, in order to provide references for subsequent research on the cold stress theory of livestock and poultry.

Key words: cold stress, heat shock protein, immune regulation, antioxidative function

中图分类号:

S852.2

郭文亮, 徐元庆, 金晓, 史彬林. 热休克蛋白在冷应激引起的炎症反应和氧化应激中的调节作用[J]. 畜牧兽医学报, 2022, 53(6): 1668-1677.

GUO Wenliang, XU Yuanqing, JIN Xiao, SHI Binlin. Moderating Role of Heat Shock Protein Under Inflammatory Response and Oxidative Stress Caused by Cold Stress[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1668-1677.

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