动物繁殖相关lncRNA的研究新进展

doi:10.11843/j.issn.0366-6964.2016.09.002

畜牧兽医学报 ›› 2016, Vol. 47 ›› Issue (9): 1749-1756.doi: 10.11843/j.issn.0366-6964.2016.09.002

动物繁殖相关lncRNA的研究新进展

贺小云，狄冉，胡文萍，王翔宇，刘秋月^*，储明星^*

（中国农业科学院北京畜牧兽医研究所，农业部畜禽遗传资源与种质创新重点实验室，北京 100193）

收稿日期:2016-04-25 出版日期:2016-09-23 发布日期:2016-09-23
通讯作者: 刘秋月，博士，副研究员，E-mail: liuqiuyue@caas.cn；储明星，博士，研究员，博士生导师，主要从事羊优异繁殖性状的分子机理研究，E-mail: mxchu@263.net
作者简介:国家自然科学基金项目(31472078；31402041；31572371)；宁夏农林科学院科技创新先导资金项目（DWJLC-2016001）；中国农业科学院科技创新工程（ASTIP-IAS13)；国家肉羊产业技术体系专项(CARS-39)；中央级公益性科研院所基本科研业务费专项（2013ywf-zd-1；2015ywf-zd-2；2015ywf-zd-8）；内蒙古自治区科技重大专项；内蒙古自治区战略性新兴产业发展专项资金计划
基金资助:
国家自然科学基金项目(31472078；31402041；31572371)；宁夏农林科学院科技创新先导资金项目（DWJLC-2016001）；中国农业科学院科技创新工程（ASTIP-IAS13)；国家肉羊产业技术体系专项(CARS-39)；中央级公益性科研院所基本科研业务费专项（2013ywf-zd-1；2015ywf-zd-2；2015ywf-zd-8）；内蒙古自治区科技重大专项；内蒙古自治区战略性新兴产业发展专项资金计划

New Research Progress in Animal Reproduction-related Long Noncoding RNAs

HE Xiao-yun，DI Ran，HU Wen-ping，WANG Xiang-yu，LIU Qiu-yue^*，CHU Ming-xing^*

(Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture，Institute of Animal Science，Chinese Academy of Agricultural Sciences，Beijing 100193，China)

Received:2016-04-25 Online:2016-09-23 Published:2016-09-23

摘要/Abstract

摘要：

长链非编码RNA（Long noncoding RNA，lncRNA）是一类长度大于200 nt，且不具有蛋白编码潜能的RNAs，在真核生物基因表达调控中发挥着重要作用。不同物种性染色体和部分印记基因的转录能力受到lncRNA的顺式调控作用。寻找与繁殖相关的lncRNA分子，研究这些lncRNA分子及其靶基因的生物学功能，阐明lncRNA在动物繁殖中的调控机制，是动物繁殖研究的一个热点。本文主要对繁殖过程中配子发生、胎盘形成和妊娠建立、激素调节、早期胚胎发育以及性别决定和性腺发育等重要阶段lncRNA 的研究进行综述，为深入探究动物繁殖调控机制提供参考。

Abstract:

Long noncoding RNA (lncRNA) is one kind of RNA which is longer than 200 nt and does not show the potential of coding protein.It has been known to play vital roles in eukaryotic gene regulation.Transcriptional capacities of sex chromosomes and some imprinted genes is regulated in cis by lncRNAs which vary among species.The researches of lncRNAs regulation in reproduction mainly focused on screening lncRNAs candidates，identifying their target genes and the biological functions，clarifying the molecular mechanisms of those lncRNAs regulation.The present review concerned with the role of lncRNAs in processes vital to reprodution，such as gametogenesis，placentation and pregnancy，sex hormone responses，early embryonic development，sex determination and gonad development stages during reproduction process.These results can give scientists new insights into the regulation mechanism of animal reproduction.

中图分类号:

S821.3

贺小云，狄冉，胡文萍，王翔宇，刘秋月，储明星. 动物繁殖相关lncRNA的研究新进展[J]. 畜牧兽医学报, 2016, 47(9): 1749-1756.

HE Xiao-yun，DI Ran，HU Wen-ping，WANG Xiang-yu，LIU Qiu-yue，CHU Ming-xing. New Research Progress in Animal Reproduction-related Long Noncoding RNAs[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(9): 1749-1756.

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动物繁殖相关lncRNA的研究新进展

New Research Progress in Animal Reproduction-related Long Noncoding RNAs

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