病毒宏基因组学的研究现状及应用

摘要/Abstract

摘要：

病毒宏基因组学（Metagenomics）是一种新兴的病毒组学研究技术，它突破了传统技术方法的局限，而直接以环境中所有病毒的遗传物质为研究对象，可以快速地鉴定出环境中所有的病毒组成，从而是一种发现新病毒，监控病毒变异的分子流行病毒学研究的有力手段。在短短的几年里，人们用这种方法发现了很多有意义的病毒，并扩大了很多病毒的宿主范围，增强了人们对环境中包括各种媒介生物的病毒组成的了解，研究领域涉及到人类肠道、动物组织、血液、水体等，充分显示出其在病毒发现、病原溯源、微生物预警等方面的实用意义。笔者在本文中简要介绍了病毒宏基因组学的进展及应用前景。

Abstract:

Metagenomics, an emerging microorganism-researching technology in recent years, directly focuses on the whole genetic materials of microorganism in all kinds of environment and breakthroughs limitations of traditional research methods, such as isolating culture, serologic reaction and PCR. Viral metagenomics has been used to discover many novel viruses in fields of human guts, animal tissues, blood, and sewer and so on, and help people to understand the virome constitutions in these environments as well as the enlargement of host ranges of many viruses, embodying the pragmatic significance of novel virus discovery, pathogen tracing and bioEW. This review briefly introduced the history of viral metagenomics and its definition and summarized some major applications of this technique and suggested that the analogous research should be carried out more in China.

中图分类号:

何彪，涂长春. 病毒宏基因组学的研究现状及应用[J]. 畜牧兽医学报, doi: .

HE Biao, TU Chang-chun. The Advances and Applications of Viral Metagenomics[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, doi: .

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