Abstract: This study was conducted to investigate the effect of Leucaena leucocephala leaf meal treated with urea on the growth performance, nutrient digestibility and blood biochemistry parameters in Nanjiang goat. Fifteen castrated Nanjiang goat (20.38 kg±1.51 kg, 6 months of age) were equally allocated into three diets with isocaloric and isonitrogenous. The concentrate for control group (CON), without Leucaena leucocephala leaf meal treated with urea (TLLM) or Leucaena leaf meal without urea treatment (ULLM), was formulated with regular protein source, whereas the concentrates for treatment groups were incorporated with 20% TLL or 20% LL to replace part of the regular protein source, respectively. All goats with TLL and LL did not show any toxic symptom after 28 days. Average daily gain in TLLM was higher than that in CON and ULLM (P=0.01), and had a lower feed to gain ratio than the other two groups. Apparent digestibility of dried matter, crude protein, organic matter, and NDF in TLLM group had a trend to be higher than that in CON and ULLM (P>0.05), especially, ADF was significantly higher in TLLM than that in ULLM (P<0.05). Hematological parameters varied in normal physiological range and there were no obvious difference among the groups (P>0.05). There was no difference of BUN, TP, GOT, GPT, T3 and T4 among the treatment groups (P>0.05), but ALB in TLLM was higher compared with the other two groups (P<0.05). Collectively, the Urea treated Leucaena leucocephala meal could improve the growth performance of Nanjiang goat by elevated nutrient digestibility without negative effects on thyroxine and tetraiodothyronine secretion, which consequently resulted in higher profit available.