人参皂甙Rb1和黄芪多糖对微血管内皮细胞分泌NO、IL-6和TNF-α的影响

畜牧兽医学报 ›› 2006, Vol. 37 ›› Issue (9): 903-907.doi:

人参皂甙Rb1和黄芪多糖对微血管内皮细胞分泌NO、IL-6和TNF-α的影响

解慧梅;胡格;索占伟;刘易通;尹龙;于同泉;路平;穆祥;黄会岭

1．河北农业大学动物科技学院，保定 071001; 2．北京农学院动物科技系，北京 102206

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-09-25 发布日期:2006-09-25

Effect of Ginsenoside Rb1 and Astragalus Polysaccharide on the Excretion of NO,IL-6 and TNF-α in Micro-vascular Endothelial Cells

XIE Hui-mei; HU Ge; SUO Zhan-wei;LIU Yi-tong;YIN Long;YU Tong-quan;LU Ping; MU Xiang;HUANG Hui-ling

1．College of Animal Science and Technology, Agricultural Univertsity of Hebei, Baoding 071001,China; 2．Department of Animal Science and Technology, Beijing Agricultural College，Beijing 102206,China

Received:1900-01-01 Revised:1900-01-01 Online:2006-09-25 Published:2006-09-25

摘要/Abstract

摘要： 取中药提取物人参皂甙Rb1和黄芪多糖作用于体外培养大鼠肠黏膜微血管内皮细胞，用硝酸还原酶法测定一氧化氮（NO）、ELISA法测定白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平的变化，为分析其免疫作用机制提供试验依据。微血管内皮细胞在人参皂甙Rb1和黄芪多糖的作用下，细胞分泌NO、IL-6和TNF-α均增多，并且随着浓度的增加内皮细胞分泌量也增加。

Abstract: Two Chinese herbal medicine extraction, ginsenoside Rb1 and astragalus polysaccharide, were supplemented into in vitro cluture system of rat micro-vascular endothelial cells.NO was detected by reduction of nitrate method and IL-6,TNF-α were detected by ELISA,the changes of those relevant factors provided experimental evidence for analyzing effect of ginsenoside Rb1 and astragalus polysaccharide. The level of NO,IL-6 and TNF-α in micro-vascular endothelial cells were enhanced significantly by ginsenoside Rb1 and astragalus polysaccharide, and showed concentration-dependent trend.

解慧梅;胡格;索占伟;刘易通;尹龙;于同泉;路平;穆祥;黄会岭. 人参皂甙Rb1和黄芪多糖对微血管内皮细胞分泌NO、IL-6和TNF-α的影响[J]. 畜牧兽医学报, 2006, 37(9): 903-907.

XIE Hui-mei;HU Ge;SUO Zhan-wei;LIU Yi-tong;YIN Long;YU Tong-quan;LU Ping;MU Xiang;HUANG Hui-ling. Effect of Ginsenoside Rb1 and Astragalus Polysaccharide on the Excretion of NO,IL-6 and TNF-α in Micro-vascular Endothelial Cells[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2006, 37(9): 903-907.

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