Abstract: To study the effects of enzyme predigested feed on growth performance and apparent digestibility of nutrients in weaned piglets, eighty (Duroc×Landrace×Yorkshine) 28 old age of weaned piglets were randomly divided into control (group Ⅰ), no enzyme addition predigesting group(group Ⅱ), common enzyme addition group(group Ⅲ), enzyme addition predigesting group(group Ⅳ) with 2 duplicates in each group which had 10 piglets each. The experimental period included 7 days of preliminary trial and 28 days of test trial. The results showed that daily gain and feed conservation rate was increased in group Ⅳ compared with groupⅠ and Ⅱ (P<0.05); Pigs fed enzyme predigested diets have significantly lower diarrhea rate than that of groupⅠ, Ⅱ and Ⅲ(P<0.01). Apparent digestibility of energy and calcium was also higher in group Ⅳ than that in groupⅠ, Ⅱ(P<0.05) and group Ⅲ (P>0.05). The apparent digestibility of phosphorus was increased significantly in group Ⅳ compared with groupⅠ, Ⅱ(P<0.01) and Ⅲ (P<0.05), there was no difference for apparent digestibility of crude protein among all groups. It was suggested that the enzyme predigested feed was effective to improve digestibility performance of nutrients and growth of weaned piglets.