Abstract: A strain of avian paramyxovirus (GPMV-2/05) was isolated from goose in Guangdong province. Some infective characters of this strain, such as IVPI,ICPI and MDT, were determined. With virulent NDV F48E9 as control,the pathogenicity of GPMV-2/05 to geese of different ages （1,14,28 and 48 days old）was examined via oral, intranasal, intramuscular and hypodermic route of challenge,respectively. The results showed that the geese can not be infected by NDV F48E9, however both geese and chicken were susceptible to GPMV-2/05 strain. According to the immunity protection test, we found that GPMV-2/05 could be prevented by the immunity of the NDV vaccine, which were NDV Ⅰ vaccine,NDV Ⅳ vaccine and the virulent strain of NDV. On the basis of serological tests,electron microscopy,physiochemical properties and histopathological study, the virus was classified as a virulent avian paramyxovirus to goose.