Abstract: To investigate the differential expression patterns of genes related to adipose deposition between Landrace (a leaner, Western breed) and Meishan pigs (a fatty, indigenous, Chinese breed). The expression changes of stearoylCoA desaturease（SCD），cytoplasmic malic enzyme（ME1）and uncoupling protein 3（UCP3）genes were measured in two pig breeds at five growth stages (30，60，90，120 and 150 days) by using qRTPCR approach. The results showed that the similar expression pattern of SCD mRNA was observed except from 90 to 120 days between the two pig breeds. Expression change of ME1 mRNA was similar between two pig breeds from 30 to 120 days, but the opposite expression pattern was exhibited during 120 to 150 days. Expression changes of UCP3 mRNA in two pig breeds were opposite except from 120 to 150 days. These results suggested that the mRNA level of SCD, ME1 and UCP3 genes in backfat tissue are different in postnatal developmental stages between Landrace and Meishan pigs, which provided some data for further study on the three genes for elucidating the molecular mechanism of fat deposition.