畜牧兽医学报 ›› 2021, Vol. 52 ›› Issue (8): 2073-2082.doi: 10.11843/j.issn.0366-6964.2021.08.001
周李生1, 颜硕1, 张圆2, 贺建宁1, 潘庆杰1*, 董焕声1*
收稿日期:
2021-02-04
出版日期:
2021-08-23
发布日期:
2021-08-21
通讯作者:
潘庆杰,主要从事动物繁殖技术与基因工程研究,E-mail:qjpan@126.com;董焕声,主要从事羊经济性状遗传解析和繁殖调控研究,E-mail:donghuansheng@163.com
作者简介:
周李生(1987-),男,安徽巢湖人,讲师,博士,主要从事动物遗传育种研究,E-mail:zls123668@qq.com;颜硕(1995-),男,山东临沂人,硕士生,主要从事羊经济性状遗传解析研究,E-mail:yanshuo2018@126.com。
基金资助:
ZHOU Lisheng1, YAN Shuo1, ZHANG Yuan2, HE Jianning1, PAN Qingjie1*, DONG Huansheng1*
Received:
2021-02-04
Online:
2021-08-23
Published:
2021-08-21
摘要: 绵羊是较早驯化的家畜之一,可为人类提供肉、毛、奶等产品,因而在我国畜牧产业中占有重要的地位。由于各地自然环境的差异和社会需要的不同,经长期的选择形成了数百个外表特征和生理习性各具特色的绵羊品种。羊角作为绵羊品种的特征性表型,承担着双重功能,发达的羊角不仅有利于公羊个体提高其在种群内的地位,拥有优先交配权,还可以有效抵御天敌的攻击,使群体免受捕食伤害;然而,随着规模化养殖的推广,羊角的存在已不利于舍内饲养管理,进而对绵羊品种的培育工作提出了新要求。目前,羊角虽在实际生产和品种培育工作中受到广泛关注,但其形态多样性及遗传调控机制的研究尚显不足。本文根据我国现有绵羊品种,对角的数量和形态、发育过程、遗传调控机制等方面的研究进行了综述,不仅能为后期鉴别绵羊羊角多样性的突变位点和主效基因提供参考,也可为绵羊的新品种培育奠定相关的理论基础。
中图分类号:
周李生, 颜硕, 张圆, 贺建宁, 潘庆杰, 董焕声. 绵羊羊角形态与遗传调控机制的研究进展[J]. 畜牧兽医学报, 2021, 52(8): 2073-2082.
ZHOU Lisheng, YAN Shuo, ZHANG Yuan, HE Jianning, PAN Qingjie, DONG Huansheng. Research Progress of Sheep Horn Morphology and Genetic Regulation Mechanism[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(8): 2073-2082.
[1] | 赵有璋.中国养羊学[M].北京:中国农业出版社,2013:01.ZHAO Y Z.Chinese sheep breeding[M].Beijing:China Agriculture Press,2013,01.(in Chinese) |
[2] | CALLAWAY E.Big horns clash with longevity in sheep[J].Nature,2013:500(7463):387. |
[3] | ROBINSON M R,PILKINGTON J G,CLUTTON-BROCK T H,et al.Environmental heterogeneity generates fluctuating selection on a secondary sexual trait[J].Curr Biol,2008,18(10):751-757. |
[4] | MARTIN A M,FESTA-BIANCHET M,COLTMAN D W,et al.Sexually antagonistic association between paternal phenotype and offspring viability reinforces total selection on a sexually selected trait[J].Biol Lett,2014,10(2):20140043. |
[5] | BONENFANT C,PELLETIER F,GAREL M,et al.Age-dependent relationship between horn growth and survival in wild sheep[J].J Anim Ecol,2009,78(1):161-171. |
[6] | LOEHR J,CAREY J,HOEFS M,et al.Horn growth rate and longevity:implications for natural and artificial selection in thinhorn sheep (Ovis dalli)[J].J Evol Biol,2007,20(2):818-828. |
[7] | 国家畜禽遗传资源委员会.中国畜禽遗传资源志:羊志[M].北京:中国农业出版社,2011:05.China Animal and Poultry Genetic Resources Committee Group.Animal genetic resources in China:Sheep and Goats[M].Beijing:China Agriculture Press,2011:05.(in Chinese) |
[8] | GREYVENSTEIN O F C,REICH C M,VAN MARLE-KOSTER,et al.Polyceraty (multi-horns)in Damara sheep maps to ovine chromosome 2[J].Anim Genet,2016,47(2):263-266. |
[9] | DYRMUNDSSON Ó R.Four-hornedness;a rare peculiarity still found in Icelandic sheep[J]. Icelandic Sheep Breeders North America Newsletter,2005,9(4):6-8. |
[10] | 杨永刚,张梅,胡耀中,等.基于转录组学的梅花鹿茸皮组织修复机制研究[J].四川动物,2019,38(4):394-401.YANG Y G,ZHANG M,HU Y Z,et al.Study on tissue repair mechanism of Sika deer antler velvet skins based on transcriptomics[J]. Sichuan Journal of Zoology,2019,38(4):394-401.(in Chinese) |
[11] | CHU W H,ZHAO H P,LI J D,et al.Custom-built tools for the study of deer antler biology[J].Front Biosci,2017,22(10):1622-1633. |
[12] | WANG D T,BERG D,BA H X,et al.Deer antler stem cells are a novel type of cells that sustain full regeneration of a mammalian organ-deer antler[J].Cell Death Dis,2019,10(6):443. |
[13] | LI C Y,SUTTIE J M,CLARK D E.Morphological observation of antler regeneration in red deer (Cervus elaphus)[J].J Morphol,2004,262(3):731-740. |
[14] | ROLF H J,KIERDORF U,KIERDORF H,et al.Localization and characterization of STRO-1+ cells in the deer pedicle and regenerating antler[J].PLoS One,2008,3(4):e2064. |
[15] | SUN H M,SUI Z G,WANG D T,et al.Identification of interactive molecules between antler stem cells and dermal papilla cells using an in vitro co-culture system[J].J Mol Histol,2020,51(1):15-31. |
[16] | LI C Y.Histogenetic aspects of deer antler development[J].Front Biosci (Elite Ed),2013,5:479-489. |
[17] | 张振祥,陈霞霞,张姗姗,等.鹿茸生长影响因子概述[J].甘肃畜牧兽医,2020,50(7):8-11.ZHANG Z X,CHEN X X,ZHANG S S,et al.An overview of antler growth influencing factors[J].Gansu Animal and Veterinary Sciences,2020,50(7):8-11.(in Chinese) |
[18] | LI C Y,GAO X H,YANG F H,et al.Development of a nude mouse model for the study of antlerogenesis-mechanism of tissue interactions and ossification pathway[J].J Exp Zool B Mol Dev Evol,2009,312B(2):118-135. |
[19] | LI C Y,YANG F H,SHEPPARD A.Adult stem cells and mammalian epimorphic regeneration-insights from studying annual renewal of deer antlers[J].Curr Stem Cell Res Ther,2009,4(3):237-251. |
[20] | PAPAIT A,VERTUA E,MAGATTI M,et al.Mesenchymal stromal cells from fetal and maternal placenta possess key similarities and differences:potential implications for their applications in regenerative medicine[J].Cells,2020,9(1):127. |
[21] | DONG Z,LI C Y,COATES D.PTN-PTPRZ signalling is involved in deer antler stem cell regulation during tissue regeneration[J]. J Cell Physiol,2021,236(5):3752-3769. |
[22] | SUN H M,SUI Z G,WANG D T,et al.Identification of interactive molecules between antler stem cells and dermal papilla cells using an in vitro co-culture system[J].J Mol Histol,2020,51(1):15-31. |
[23] | SUI Z G,SUN H M,WENG Y J,et al.Quantitative proteomics analysis of deer antlerogenic periosteal cells reveals potential bioactive factors in velvet antlers[J].J Chromatogr A,2020,1609:460496. |
[24] | FELEKE M,BENNETT S,CHEN J Z,et al.New physiological insights into the phenomena of deer antler:a unique model for skeletal tissue regeneration[J].J Orthop Transl,2021,27:57-66. |
[25] | HUGHES I,SAITO M,SCHLESINGER P H,et al.Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium[J].Proc Natl Acad Sci U S A,2007,104(29):12023-12028. |
[26] | BETANCUR P,BRONNER-FRASER M,SAUKA-SPENGLER T.Assembling neural crest regulatory circuits into a gene regulatory network[J].Annu Rev Cell Dev Biol,2010,26:581-603. |
[27] | PAN Z Y,LI S D,LIU Q,et al.Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization[J].GigaScience,2018,7(4):giy019. |
[28] | HASEEB A,LEFEBVRE V.The SOXE transcription factors-SOX8,SOX9and SOX10-share a bi-partite transactivation mechanism[J].Nucleic Acids Res,2019,47(13):6917-6931. |
[29] | MERTELMEYER S,WEIDER M,BAROTI T,et al.The transcription factor Sox10 is an essential determinant of branching morphogenesis and involution in the mouse mammary gland[J].Sci Rep,2020,10:17807. |
[30] | WANG H M,CHIRSHEV E,HOJO N,et al.The Epithelial-Mesenchymal Transcription Factor SNAI1 represses transcription of the tumor suppressor miRNA let-7 in cancer[J].Cancers(Basel),2021,13(6):1469. |
[31] | WEI Q Z,NAKAHARA F,ASADA N,et al.Snai2 maintains bone marrow niche cells by repressing osteopontin expression[J].Dev Cell,2020,53(5):503-513:e5. |
[32] | ZHANG F C,GU X K,YI S,et al.Dysregulated transcription factor TFAP2A after peripheral nerve injury modulated schwann cell phenotype[J].Neurochem Res,2019,44(12):2776-2785. |
[33] | CHEN L Q,ZHANG H L,ZHANG L T,et al.Cas9 protein triggers differential expression of inherent genes especially NGFR expression in 293T Cells[J].Cell Mol Bioeng,2020,13(1):61-72. |
[34] | MICALE L,MORLINO S,SCHIRIZZI A,et al.Exon-trapping assay improves clinical interpretation of COL11A1 and COL11A2 intronic variants in stickler syndrome Type 2 and otospondylomegaepiphyseal dysplasia[J].Genes (Basel),2020,11(12):1513. |
[35] | WANG Y,ZHAGN C Z,WANG N N,et al.Genetic basis of ruminant headgear and rapid antler regeneration[J]. Science, 2019,364(6446):eaav6335. |
[36] | JOURDEUIL K,TANEYHILL L A.The gap junction protein connexin 43 controls multiple aspects of cranial neural crest cell development[J].J Cell Sci,2020,133(4):jcs235440. |
[37] | MALAGON S G G MG,DOBSON L,MUÑOZ A M L,et al.Dissection,culture and analysis of primary cranial neural crest cells from mouse for the study of neural crest cell delamination and migration[J].J Vis Exp,2019(152):10.3791/60051. |
[38] | WISZNIAK S,SCHWARZ Q.Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration[J].BMC Neurosci,2019,20(1):21. |
[39] | KIERDORF U,LI C Y,PRICE J S.Improbable appendages:deer antler renewal as a unique case of mammalian regeneration[J].Semin Cell Dev Biol,2009,20(5):535-542. |
[40] | MOUNT J G,MUZYLAK M,ALLEN S,et al.Evidence that the canonical Wnt signalling pathway regulates deer antler regeneration[J]. Dev Dyn,2006,235(5):1390-1399. |
[41] | 严飞,江宏兵.神经嵴细胞与颅颌面骨骼的发生[J].口腔医学,2010,30(3):174-176.YAN F,JIANG H B.Neural crest cells and the development of cranio-maxillofacial bones[J].Stomatology,2010,30(3):174-176.(in Chinese) |
[42] | 蒋锐达,赵敏,赵三军,等.胚胎发育中神经嵴细胞迁移机制的研究进展[J].基因组学与应用生物学,2018,37(9):3799-3809.JIANG R D,ZHAO M,ZHAO S J,et al.Research advance on the migration mechanism of neural crest cell during embryonic development[J].Genomics and Applied Biology,2018,37(9):3799-3809.(in Chinese) |
[43] | KARDOS M,LUIKART G,BUNCH R,et al.Whole-genome resequencing uncovers molecular signatures of natural and sexual selection in wild bighorn sheep[J].Mol Ecol,2015,24(22):5616-5632. |
[44] | LÜHKEN G,KREBS S,ROTHAMMER S,et al.The 1.78-kb insertion in the 3'-untranslated region of RXFP2 does not segregate with horn status in sheep breeds with variable horn status[J].Genet Sel Evol,2016,48(1):78. |
[45] | COLTMAN D W,PEMBERTON J M. Appendix 2-Inheritance of coat colour and horn type in Hirta Soay sheep[J].Soay Sheep,2003:321-327. |
[46] | BERALDI D,MCRAE A F,GRATTEN J,et al.Development of a linkage map and mapping of phenotypic polymorphisms in a free-living population of Soay sheep(Ovis aries)[J].Genetics,2006,173(3):1521-1537. |
[47] | WIEDEMAR N,DRÖGEMÜLLER C.A 1.8-kb insertion in the 3'-UTR of RXFP2 is associated with polledness in sheep[J].Anim Genet,2015,46(4):457-461. |
[48] | KIJAS J W,LENSTRA J A,HAYES B,et al.Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection[J].PLoS Biol,2012,10(2):e1001258. |
[49] | JOHNSTON S E,MCEWAN J C,PICKERING N K,et al.Genome-wide association mapping identifies the genetic basis of discrete and quantitative variation in sexual weaponry in a wild sheep population[J].Mol Ecol,2011,20(12):2555-2566. |
[50] | DUIJVESTEIJN N,BOLORMAA S,DAETWYLER H D,et al.Genomic prediction of the polled and horned phenotypes in Merino sheep[J].Genet Sel Evol,2018,50(1):28. |
[51] | HE X H,ZHOU Z K,PU Y B,et al.Mapping the four-horned locus and testing the polled locus in three Chinese sheep breeds[J].Anim Genet,2016,47(5):623-627. |
[52] | KIJAS J W,HADFIELD T,SANCHEZ M N,et al.Genome-wide association reveals the locus responsible for four-horned ruminant[J].Anim Genet,2016,47(2):258-262. |
[53] | REN X,YANG G L,PENG W F,et al.A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep(Ovis aries)[J].Sci Rep,2016,6:21111. |
[54] | ALVAREZ F.Horns and fighting in male Spanish ibex,Capra pyrenaica[J].J Mammal,1990,71(4):608-616. |
[55] | LINCOLN G A.Reproductive seasonality and maturation throughout the complete life-cycle in the mouflon ram(Ovis musimon)[J].Anim Reprod Sci,1998,53(1-4):87-105. |
[56] | SANTIAGO-MORENO J,GÓMEZ-BRUNET A,TOLEDANO-DIÍAZ A,et al.Influence of age on the relationship between annual changes in horn growth rate and prolactin secretion in the European mouflon (Ovis gmelini musimon)[J].Anim Reprod Sci,2005,85(3-4):251-261. |
[57] | MOLIK E,BŁASIAK M,PUSTKOWIAK H.Impact of photoperiod length and treatment with exogenous melatonin during pregnancy on chemical composition of sheep's milk[J].Animals,2020,10(10):1721. |
[58] | TROTTA R J,LEMLEY C O,VONNAHME K A,et al.Effects of nutrient restriction and melatonin supplementation from mid-to-late gestation on maternal and fetal small intestinal carbohydrase activities in sheep[J].Domest Anim Endocrinol, 2021,74:106555. |
[59] | FLORES-GIL V N,TOLEDANO-DÍAZ A,VELÁZQUEZ R,et al.Role of changes in plasma prolactin concentrations on ram and buck sperm cryoresistance[J].Domest Anim Endocrinol,2021,76:106624. |
[60] | TOLEDANO-DÍAZ A,SANTIAGO-MORENO J,GÓMEZ-BRUNET A,et al.Horn growth related to testosterone secretion in two wild Mediterranean ruminant species:the Spanish ibex(Capra pyrenaica hispanica) and European mouflon(Ovis orientalis musimon)[J].Anim Reprod Sci,2007,102(3-4):300-307. |
[61] | LOEHR J,CAREY J,O'HARA R B,et al.The role of phenotypic plasticity in responses of hunted thinhorn sheep ram horn growth to changing climate conditions[J].J Evol Biol,2010,23(4):783-790. |
[62] | LINCOLN G A,KLANDORF H,ANDERSON N.Photoperiodic control of thyroid function and wool and horn growth in rams and the effect of cranial sympathectomy[J].Endocrinology,1980,107(5):1543-1548. |
[63] | 杨敏,宋伸,陈潇飞,等.光控对内蒙古绒山羊血液中褪黑激素和催乳素及产绒性能的影响[J].家畜生态学报, 2017,38(12):24-28.YANG M,SONG S,CHEN X F,et al.Effects of short photoperiod on melatonin and prolactin hormone and cashmere growth for cashmere goat[J].Acta Ecologae Animalis Domastici,2017,38(12):24-28.(in Chinese) |
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