哺乳动物原始卵泡形成与发育的研究进展

doi:10.11843/j.issn.0366-6964.2020.03.002

摘要/Abstract

摘要： 在大多数雌性哺乳动物中，早期原始卵泡的形成主要包括3个过程：原始生殖细胞的迁移、生殖细胞减数分裂和生殖细胞巢破裂。原始卵泡形成与发育过程涉及到诸多因子和信号通路的调节作用，且原始卵泡库的大小及储备能力将决定雌性动物终生生殖能力。本文就参与原始卵泡形成和发育过程中的因子和信号通路作一综述，旨在深入了解参与原始卵泡形成与发育的细胞和分子机制，为维持原始卵泡库及促进原始卵泡激活提供研究思路。

关键词: 哺乳动物, 卵巢, 原始卵泡, 形成与发育, 信号通路

Abstract: In most female mammals, the migration of primordial germ cells, germ cells meiosis, and breakdown of germ cell nests are regarded as the 3 critical processes for the formation of early primordial follicles. In addition, there are some special factors and signaling pathways regulating the formation and development of primordial follicles. However, the reproductive ability of a female is determined by the size and reserve capacity of her primordial follicle pool. This review summarizes the factors and signaling pathways involved in the formation and development of primordial follicles, with the aim of understanding the cellular and molecular mechanisms and providing research ideas for maintaining the primordial follicle pool and promoting primordial follicle activation.

Key words: mammal, ovary, primordial follicle, formation and development, signaling pathway

中图分类号:

S821.3

阳美霞, 张羽芳, 汤亚茹, 张虹亮, 王水莲. 哺乳动物原始卵泡形成与发育的研究进展[J]. 畜牧兽医学报, 2020, 51(3): 417-425.

YANG Meixia, ZHANG Yufang, TANG Yaru, ZHANG Hongliang, WANG Shuilian. Research Progresses on the Formation and Development of Primordial Follicles in Mammals[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(3): 417-425.

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