印记基因对动物胎盘调控的研究进展

畜牧兽医学报

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印记基因对动物胎盘调控的研究进展

康倩¹，崔焕忠^1*，孙玉成²，高云航¹,范译文¹，刘二战¹

（1.吉林农业大学动物科技学院，长春 130118； 2.长春军事医学科学院军事兽医研究所，长春 130122）

收稿日期:2012-05-31 出版日期:2013-02-23 发布日期:2013-02-23
通讯作者: 崔焕忠，副教授，E-mail：huanzhongcui@163.com
作者简介:康倩（1986-），女，山东济南人，硕士生，主要从事临床兽医诊疗新技术的研究，E-mail: 512861132@qq.com
基金资助:
吉林省重大科技攻关项目（09ZDGG008）

Research Progress on Regulation of Imprinted Genes for Animal Placental Phenotype

KANG Qian¹，CUI Huan-zhong^1*，SUN Yu-cheng²，GAO Yun-hang¹，FAN Yi-wen¹，LIU Er-zhan¹

（1.College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China; 2.Institute of Military Hippiater, Changchun Academy of Military Medical Sciences, Changchun 130122, China）

Received:2012-05-31 Online:2013-02-23 Published:2013-02-23

摘要/Abstract

摘要：

印记基因是仅表达亲本一方遗传信息的一类基因。通过大量的研究表明，印记基因对胎儿、胎盘的生长发育及胎儿出生后行为等方面的调控都具有显著作用。印记基因具有决定胎盘运输能力的作用，并能调节胎盘的生长、形态和转运能力。当胎盘所处环境或胎盘表型发生变化时，印记基因能够通过改变胎盘一定的表观遗传状态来适应当时的营养环境。印记基因类似营养传感器能优化胎儿获得营养。印记基因对胎盘的表观遗传具有重要调控作用。

Abstract:

Imprinted genes only express the genetic information from male parent or female parent. A large number of researches showed that imprinted genes have important roles in the fetus growth, fetus development, function of the placenta and postnatal behavior. Imprinted genes have been shown to determine the transport capacity of the placenta by regulating its growth, morphology and transporter capacity. When the environment of placenta or the placenta phenotype changes, the imprinted genes can adapt to the prevailing nutritional environment, by varying their placental epigenetic status. Imprinted genes may act as nutrient sensors and optimize the fetal acquisition of nutrients for growth. These genes have a major role in the epigenetic regulation of placental phenotype.

中图分类号:

S813.3

康倩，崔焕忠，孙玉成，高云航,范译文，刘二战. 印记基因对动物胎盘调控的研究进展[J]. 畜牧兽医学报, doi: .

KANG Qian，CUI Huan-zhong，SUN Yu-cheng，GAO Yun-hang，FAN Yi-wen，LIU Er-zhan. Research Progress on Regulation of Imprinted Genes for Animal Placental Phenotype[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, doi: .

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印记基因对动物胎盘调控的研究进展

Research Progress on Regulation of Imprinted Genes for Animal Placental Phenotype

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