畜牧兽医学报

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猪繁殖与呼吸综合征病毒结构和非结构蛋白生物学功能研究进展

张松林1,沈志强1,2*,刘磊2,马永彪2,刘吉山1   

  1. (1.山东省滨州畜牧兽医研究院,滨州 256600; 2.山东省绿都生物科技有限公司,滨州256600)
  • 收稿日期:2012-05-10 出版日期:2012-11-26 发布日期:2012-11-26
  • 通讯作者: 沈志强,研究员,E-mail: bzshenzq@163.com
  • 作者简介:张松林(1978-),男,吉林公主岭人,助理研究员,博士,主要从事分子病毒学研究,Tel:0543-3405418,E-mail: jlgzlzsl@qq.com
  • 基金资助:

    国家自然科学基金项目(31201913);山东省技术创新项目(201220916003)

Advance on Biological Functions of Structural and Non-structural Proteins of Porcine Reproductive and Respiratory Syndrome Virus

ZHANG Song-lin1, SHEN Zhi-qiang1,2*, LIU Lei2, MA Yong-biao2, LIU Ji-shan1   

  1. (1. Shandong Binzhou Animal Science &Veterinary Medicine Academy, Binzhou 256600, China;
    2. Shandong Lvdu Bio-technology Company Llimited, Binzhou Shandong, Binzhou 256600, China)
  • Received:2012-05-10 Online:2012-11-26 Published:2012-11-26

摘要: 猪繁殖与呼吸综合征严重危害着养猪业的健康发展,给养猪业造成了巨大的经济损失。由于猪繁殖与呼吸综合征病毒(PRRSV)介导的特殊的免疫逃避机制以及抗原性基因的异质性等特征,目前疫苗产品不能提供十分有效的保护。作者就PRRSV结构和非结构蛋白生物学功能的最新研究进展进行归纳总结,以期为PRSSV防控,新型疫苗设计等提供参考。

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be a threat, and causes huge economic losses in the swine industry. Commercial vaccines are still ineffective as they suffer from both PRRSV-induced immune evasion strategies and the antigenic heterogeneity of the virus. In this paper, the latest research progress of structural and nonstructural proteins of PRRSV are summarized, such as biological functions, which seems to be effective in PRSSV prevention and control, design of new vaccines.

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