Abstract: Thirty-two purebred Lantang piglets of the same age derived from multiparous sow were slaughtered at the newborn, 3, 21 and 35 d of age respectively. Blood sample and tissues samples including liver and longissimus muscle were collected each time. Concentrations of IGF-1 in serum and in liver and muscle were determined by radio-immunoassay (RIA). Growth hormone receptor (GHR) specific binding activity in the membrane of liver cell and in muscle cell was determined by the method of radioligand binding assay(RBA). Real-time polymerase chain reaction (PCR) quantifications of IGF-1 mRNA and GHR mRNA from liver, muscle were carried out by DNA binding dye method using SYBR Green PCR Core Reagents Kit in Rotor-gene 2 000 Real-time Cycler. The results showed that: 1. Serum IGF-1 levels of newborn piglets were significantly higher than any other days observed (P<0.05).Concentrations of IGF-1 in longissimus muscle were higher than in liver per micrograms protein, longissimus muscle IGF-1 levels were higher at 3, 21and 35 d than that of newborn (P<0.05).2. Growth hormone receptor (GHR) specific binding activity in the membrane of liver cell was highest at newborn (P<0.05). Growth hormone receptor (GHR) specific binding activity in the membrane of liver cell was higher than in the membrane of longissimus muscle cell.3.IGF-1 and GHR mRNA levels in liver were significantly higher than longissimus muscle (P<0.05). Liver IGF-1 mRNA levels in newborn and 21 d were significantly higher than 3 d and 35 d(P<0.05). Liver GHR mRNA levels of newborn were significantly higher than any other days observed (P<0.05). Longissimus muscle IGF-1 and GHR mRNA levels of newborn were significantly higher than any other days observed (P<0.05).