显性效应对内蒙古绒山羊产绒量和绒纤维直径育种值估计准确性的影响

doi:10.11843/j.issn.0366-6964.2025.02.009

畜牧兽医学报 ›› 2025, Vol. 56 ›› Issue (2): 571-581.doi: 10.11843/j.issn.0366-6964.2025.02.009

显性效应对内蒙古绒山羊产绒量和绒纤维直径育种值估计准确性的影响

习海娇¹(), 李金泉¹^,², 张燕军¹, 王瑞军¹, 吕琦¹, 梅步俊⁴, 王娜⁵, 苏蕊¹, 王志英¹^,³^,*()

1. 内蒙古农业大学动物科学学院, 呼和浩特 010018
2. 农业农村部肉羊遗传育种重点实验室, 呼和浩特 010018
3. 内蒙古自治区羊遗传育种与繁殖重点实验室, 呼和浩特 010018
4. 河套学院农学系, 巴彦淖尔 015000
5. 内蒙古亿维白绒山羊有限责任公司, 鄂尔多斯 016105

收稿日期:2024-06-14 出版日期:2025-02-23 发布日期:2025-02-26
通讯作者: 王志英 E-mail:xihaijiao456@163.com;wzhy0321@126.com
作者简介:习海娇(2001-), 女，吉林四平人，硕士生，主要从事羊遗传资源保护与育种方面的研究，E-mail: xihaijiao456@163.com
基金资助:
国家重点研发计划项目(2022YFD1300201；2022YFD1300204)；内蒙古自治区高等学校“青年科技英才支持计划”(NJYT22038)；财政部和农业农村部：国家绒毛用羊产业技术体系项目(CARS-39)；内蒙古农业大学高水平成果培育专项(QT202201)；内蒙古自治区高等学校创新团队发展计划项目(NMGIRT2322)；内蒙古自治区直属高校基本科研业务费项目(BR220112)

Influence of Dominance Effects on the Accuracy of Breeding Value Estimation of Cashmere Production and Cashmere Diameter in Inner Mongolia Cashmere Goats

XI Haijiao¹(), LI Jinquan¹^,², ZHANG Yanjun¹, WANG Ruijun¹, LÜ Qi¹, MEI Bujun⁴, WANG Na⁵, SU Rui¹, WANG Zhiying¹^,³^,*()

1. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
2. Key Laboratory of Meat Sheep Genetic Breeding of the Ministry of Agriculture and Rural Affairs, Hohhot 010018, China
3. Key Laboratory of Sheep Genetic Breeding and Reproduction in Inner Mongolia Autonomous Region, Hohhot 010018, China
4. Department of Agriculture, Hetao University, Bayannur 015000, China
5. Inner Mongolia Yi-Wei White Down Goat Limited Liability Company, Erdos 016105, China

Received:2024-06-14 Online:2025-02-23 Published:2025-02-26
Contact: WANG Zhiying E-mail:xihaijiao456@163.com;wzhy0321@126.com

摘要/Abstract

摘要：

旨在分析动物遗传评估模型中加入显性效应是否可以有效提高内蒙古绒山羊绒毛性状育种值预测的准确性。本研究基于课题组前期积累的健康状况良好的内蒙古绒山羊(阿尔巴斯型)2 256只个体的70K SNP芯片测序数据，收集整理1至8岁个体的绒毛性状(绒纤维直径和产绒量)生产性能数据和系谱记录，根据是否考虑显性效应，建立两个动物模型，利用BLUP和GBLUP方法进行遗传参数及育种值的估计，进一步通过交叉验证的方法评价绒毛性状育种值估计的准确性，确定最佳遗传评估模型。最后建立多变量动物模型进行两个性状的遗传相关及育种值准确性估计，对比单性状和多性状模型下估计遗传参数及育种值准确性的差异。研究结果表明：当遗传评估模型中不考虑显性效应时，基于BLUP和GBLUP法估计产绒量的加性遗传力分别为0.156和0.215，育种值估计准确性分别为27.58%和60.33%；绒纤维直径的加性遗传力为0.252和0.292，育种值估计准确性为28.08%和62.33%。在动物模型中同时考虑加性和显性效应时，基于BLUP和GBLUP法估计产绒量的加性遗传力分别为0.150和0.200，显性遗传力为0.147和0.070，育种值估计准确性分别为38.50%和72.62%；绒纤维直径的加性遗传力为0.263和0.290，显性遗传力为0.288和0.026，育种值估计准确性为39.66%和65.97%。最佳模型下，产绒量和绒纤维直径的遗传相关为0.340 0，表型相关为0.038 5。产绒量和绒纤维直径育种值估计准确性比基于单性状下的育种值估计准确性分别提高9.81%~19.43%和14.01%~21.97%。综上所述，产绒量属于中等偏低遗传力，绒纤维直径属于中等偏高遗传力，两个性状的遗传相关相对较小，说明对产绒量的选育提高不会造成绒纤维直径的变粗。GBLUP法的估计的各性状育种值准确性显著高于BLUP法，产绒量提高了10.92%~12.29%，绒纤维直径提高了3.64% ~11.58%。基于多性状动物模型下育种值估计准确性高于单性状动物模型。当模型中同时考虑加性效应和显性效应时，可以显著提高基因组预测准确性，说明对内蒙古绒山羊产绒量和绒纤维直径进行选育过程中应该考虑显性效应的影响。

关键词: 内蒙古绒山羊, 绒纤维直径, 产绒量, 显性效应, 育种值估计准确性

Abstract:

The aim of this study was to analyze that whether the accuracy of breeding value prediction for cashmere traits in Inner Mongolia cashmere goats was improved if dominance effects were added in animal genetic evaluation models. Based on the Illumina GGP_Goat_70K BeadChip sequencing data from 2 256 individuals of Inner Mongolia cashmere goats (Aerbas type), the phenotype and pedigree records of cashmere traits(cashmere diameter, cashmere production) were collected from individuals at age 1 to 8 years old.Two animal models were established according to whether dominance effects were taken into account or not. The genetic parameters and breeding values were estimated using the BLUP and GBLUP methods.And the accuracy of the estimated breeding values of cashmere traits was further evaluated by the cross-validation method, which was used to determine the optimal model. Finally, a multivariate animal model was established to estimate the genetic correlation and accuracy of breeding value prediction for both of the traits.And the differences in genetic parameters and breeding value accuracy between single trait and multi trait models were compared. The results showed that when the dominance effects were not considered in the animal model, the additive heritabilities for cashmere production using the BLUP and GBLUP methods were 0.156 and 0.215, and the accuracy of breeding value estimation was 27.58% and 60.33%, respectively; and the additive heritabilities for cashmere diameter were 0.252 and 0.292, and the accuracy of breeding value estimation was 28.08% and 62.33%, respectively. When both additive and dominance effects were considered in the animal model, the additive heritabilities for cashmere production using the BLUP and GBLUP methods were 0.150 and 0.200, and the dominant heritabilities were 0.147 and 0.070, with breeding value estimation accuracies of 38.50%and 72.62%, respectively; And the additive heritabilities for cashmere diameter were 0.263 and 0.290, and the dominant heritabilities were 0.288 and 0.026, and the accuracy of breeding value estimation was 39.66% and 65.97%, respectively.Under the best model, the genetic correlation between cashmere production and cashmere diameter was 0.340 0, and the phenotypic correlation was 0.038 5.Compared to that in single trait animal model, the accuracy of breeding value estimation for cashmere production and cashmere diameter was increased by 9.81%-19.43% and 14.01%-21.97%, respectively. In summary, the cashmere production have moderate to low heritability, and the cashmere diameter have moderate to high heritability. The genetic correlation between the two traits is relatively small, indicating that genetic improving for cashmere production will not cause thickening of cashmere diameter. The accuracy of breeding values estimation for the two traits by GBLUP method is significantly higher than that with BLUP method, with a 10.92% to 12.29% increase in cashmere production and a 3.64% to 11.58% increase in cashmere diameter. The accuracy of breeding value estimation under multi trait animal models is higher than that with single trait animal models. When both additive and dominance effects are considered in the animal model, the accuracy of genomic prediction can be significantly improved, indicating that the influence of dominance effects should be considered in the breeding process of Inner Mongolia cashmere goats in terms of cashmere production and cashmere diameter.

Key words: Inner Mongolia cashmere goat, cashmere diameter, cashmere production, dominance effects, accuracy of estimated breeding value

中图分类号:

S827.2

习海娇, 李金泉, 张燕军, 王瑞军, 吕琦, 梅步俊, 王娜, 苏蕊, 王志英. 显性效应对内蒙古绒山羊产绒量和绒纤维直径育种值估计准确性的影响[J]. 畜牧兽医学报, 2025, 56(2): 571-581.

XI Haijiao, LI Jinquan, ZHANG Yanjun, WANG Ruijun, LÜ Qi, MEI Bujun, WANG Na, SU Rui, WANG Zhiying. Influence of Dominance Effects on the Accuracy of Breeding Value Estimation of Cashmere Production and Cashmere Diameter in Inner Mongolia Cashmere Goats[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(2): 571-581.

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性状 Trait	性别 Sex	样本量 Sample	平均值 Mean	标准差 Standard deviation	变异系数/% Variation coefficient	最大值 Maximum	最小值 Minimum
产绒量/g Cashmere production	公	613	1 001.62	430.41	43.08	2 390	118
	母	8 570	726.37	187.36	25.79	1 910	101
	总	918 3	740.31	215.28	29.07	2 390	101
绒纤维直径/μm Cashmere diameter	公	613	15.06	1.04	6.91	18.40	12.82
	母	8 570	15.24	0.78	5.11	18.66	12.73
	总	9 183	15.23	0.81	5.31	18.66	12.73

方法 Method	σ_a²	σ_d²	σ_d_d²	σ_e²	σ_y²	h_add²	h_dom²	r	logL
BLUP(add)	6 174.9	—	7 620.1	25 700.2	39 495.2	0.156	—	0.35	-51 344.77
BLUP(add+dom)	5 918.4	5 784.2	2 045.9	25 708.7	39 457.2	0.150	0.147	0.35	-51 345.43
GBLUP (add)	8 249.1	—	4 718.3	25 400.6	38 368.0	0.215	—	0.34	-46 285.38
GBLUP(add+dom)	7 684.9	2 679.4	2 639.6	25 396.3	38 400.2	0.200	0.070	0.34	-46 286.98

方法 Method	σ_a²	σ_d²	σ_d_d²	σ_e²	σ_y²	h_add²	h_dom²	r	logL
BLUP(add)	0.130 3	—	0.062 7	0.324 6	0.517 6	0.252	—	0.37	-602.89
BLUP(add+dom)	0.134 4	0.147 6	0.000 2	0.229 9	0.511 9	0.263	0.288	0.55	-722.44
GBLUP (add)	0.148 9	—	0.035 9	0.316 5	0.501 3	0.292	—	0.37	-387.92
GBLUP(add+dom)	0.145 1	0.012 9	0.026 5	0.316 5	0.501 0	0.290	0.026	0.39	-388.08

方法 Method	准确性/% Accuracy	准确性标准差 Standard deviation of accuracy
BLUP (add)	27.58^b	0.138 6
BLUP(add+dom)	38.50^a	0.279 0
GBLUP (add)	60.33^b	0.062 7
GBLUP(add+dom)	72.62^a	0.100 1

方法 Method	准确性/% Accuracy	准确性标准差 Standard deviation of accuracy
BLUP (add)	28.08^b	0.150 7
BLUP(add+dom)	39.66^a	0.305 8
GBLUP (add)	62.33^b	0.076 3
GBLUP(add+dom)	65.97^a	0.096 7

显性效应对内蒙古绒山羊产绒量和绒纤维直径育种值估计准确性的影响

Influence of Dominance Effects on the Accuracy of Breeding Value Estimation of Cashmere Production and Cashmere Diameter in Inner Mongolia Cashmere Goats

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性状 Trait	绒纤维直径 Cashmere diameter	产绒量 Cashmere production
绒纤维直径 Cashmere diameter	0.260 3(0.325 5)	0.386 8(0.340 0)
产绒量 Cashmere production	0.038 5(0.038 5)	0.145 8(0.189 5)

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