[1] |
BLÜHER M.Obesity:global epidemiology and pathogenesis[J].Nat Rev Endocrinol,2019,15(5):288-298.
|
[2] |
HEYMSFIELD S B,WADDEN T A.Mechanisms,pathophysiology,and management of obesity[J].N Engl J Med,2017,376(3): 254-266.
|
[3] |
CZECH M P.Insulin action and resistance in obesity and type 2 diabetes[J].Nat Med,2017,23(7):804-814.
|
[4] |
WANSA K D,HARRIS J M,MUSCAT G E.The activation function-1 domain of Nur77/NR4A1 mediates trans-activation,cell specificity,and coactivator recruitment[J].J Biol Chem,2002,277(36):33001-33011.
|
[5] |
PEAREN M A,MUSCAT G E O.Orphan nuclear receptors and the regulation of nutrient metabolism:understanding obesity[J].Physiology,2012,27(3):156-166.
|
[6] |
MOHAN H M,AHERNE C M,ROGERS A C,et al.Molecular pathways:the role of NR4A orphan nuclear receptors in cancer[J].Clin Cancer Res,2012,18(12):3223-3228.
|
[7] |
BURRIS T P,BUSBY S A,GRIFFIN P R.Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity[J]. Chem Biol,2012,19(1):51-59.
|
[8] |
SAFE S,JIN U H,MORPURGO B,et al.Nuclear receptor 4A(NR4A) family-orphans no more[J].J Steroid Biochem Mol Biol,2016,157:48-60.
|
[9] |
HAMERS A A,HANNA R N,NOWYHED H,et al.NR4A nuclear receptors in immunity and atherosclerosis[J].Curr Opin Lipidol,2013,24(5):381-385.
|
[10] |
ZHANG L,WANG Q,LIU W,et al.The orphan nuclear receptor 4A1:a potential new therapeutic target for metabolic diseases[J].J Diabetes Res,2018,2018:9363461.
|
[11] |
DAI W W,DIERSCHKE S K,TORO A L,et al.Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression[J].Biochim Biophys Acta Mol Basis Dis,2018,1864(12):3568-3576.
|
[12] |
ZHANG Y,FEDERATION A J,KIM S,et al.Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity[J].J Clin Invest,2018,128(11):4898-4911.
|
[13] |
LIU L L,WU Z Y,CHEN A X,et al.ISG12a and its interaction partner NR4A1 are involved in TRAIL-induced apoptosis in hepatoma cells[J].J Cell Mol Med,2019,23(5):3520-3529.
|
[14] |
YANG Y F,XIE F Y,QIN D D,et al.The orphan nuclear receptor NR4A1 attenuates oxidative stress-induced β cells apoptosis via up-regulation of glutathione peroxidase 1[J].Life Sci,2018,203:225-232.
|
[15] |
FREIRE P R,CONNEELY O M.NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling[J].Blood,2018,131(10):1081-1093.
|
[16] |
HEDRICK E,MOHANKUMAR K,LACEY A,et al.Inhibition of NR4A1 promotes ROS accumulation and IL24-dependent growth arrest in rhabdomyosarcoma[J].Mol Cancer Res,2019,17(11):2221-2232.
|
[17] |
ZHU Y,HAN X Q,SUN X J,et al.Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy[J].Apoptosis,2020,25(5-6):321-340.
|
[18] |
SHENG J Q,LI H Y,DAI Q,et al.NR4A1 promotes diabetic nephropathy by activating Mff-mediated mitochondrial fission and suppressing parkin-mediated mitophagy[J].Cell Physiol Biochem,2018,48(4):1675-1693.
|
[19] |
秦丹丹.NR4A1与脂肪细胞分化和脂质积累的关联及其机制研究[D].济南:山东大学,2019.QIN D D.The effect and related mechanism of orphan nuclear receptor NR4A1 on adipocyte differentiation and lipid accumulation[D].Ji’nan:Shandong University,2019.(in Chinese)
|
[20] |
ZHAO N Q,LI X Y,FENG Y,et al.The nuclear orphan receptor Nur77 alleviates palmitate-induced fat accumulation by down-regulating G0S2 in HepG2 cells[J].Sci Rep,2018,8(1):4809.
|
[21] |
JUNG Y S,LEE H S,CHO H R,et al.Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo[J].Int J Obes (Lond),2019,43(5):952-962.
|
[22] |
YI M,YOU Y M,SUN Z L.Interaction of nuclear receptor subfamily 4 group a member 1(Nr4a1) and liver linase B1(LKB1) mitigates type 2 diabetes mellitus by activating monophosphate-activated protein kinase (AMPK)/Sirtuin 1(SIRT1) axis and inhibiting nuclear factor-kappa B (NF-κB) activation[J].Med Sci Monit,2020,26:e920278.
|
[23] |
许晴,林森,朱江江,等.山羊肌内前体脂肪细胞诱导分化过程中内参基因的表达稳定性分析[J].畜牧兽医学报,2018,49(5):907-918.XU Q,LIN S,ZHU J J,et al.The expression stability analysis of reference genes in the process of goat intramuscular preadipocytes differentiation in goat[J].Acta Veterinaria et Zootechnica Sinica,2018,49(5):907-918.(in Chinese)
|
[24] |
LIVAK K J,SCHMITTGEN T D.Analysis of relative gene expression data using real-time quantitative PCR and the method[J].Methods,2001,25(4):402-408.
|
[25] |
KOKOROISHI K,NAKASHIMA A,DOI S,et al.High glucose promotes TGF-β1 production by inducing FOS expression in human peritoneal mesothelial cells[J].Clin Exp Nephrol,2016,20(1):30-38.
|
[26] |
PANG W J,WANG Y,WEI N,et al.Sirt1 inhibits Akt2-mediated porcine adipogenesis potentially by direct protein-protein interaction[J].PLoS One,2013,8(8):e71576.
|
[27] |
LIU L Q,LI F E,DENG C Y,et al.Molecular cloning,tissue expression and association of porcine NR4A1 gene with reproductive traits[J].Mol Biol Rep,2011,38(1):103-114.
|
[28] |
NAKAI A,KARTHA S,SAKURAI A,et al.A human early response gene homologous to murine nur77 and rat NGFI-B,and related to the nuclear receptor superfamily[J].Mol Endocrinol,1990,4(10):1438-1443.
|
[29] |
FUMOTO T,YAMAGUCHI T,HIROSE F,et al.Orphan nuclear receptor Nur77 accelerates the initial phase of adipocyte differentiation in 3T3-L1 cells by promoting mitotic clonal expansion[J].J Biochem,2007,141(2):181-192.
|
[30] |
VEUM V L,DANKEL S N,GJERDE J,et al.The nuclear receptors NUR77,NURR1 and NOR1 in obesity and during fat loss[J].Int J Obes (Lond),2012,36(9):1195-1202.
|
[31] |
QIN D D,YANG Y F,PU Z Q,et al.NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression[J].J Cell Mol Med,2018,22(10):4709-4720.
|
[32] |
CHAO L C,BENSINGER S J,VILLANUEVA C J,et al.Inhibition of adipocyte differentiation by Nur77,Nurr1,and Nor1[J].Mol Endocrinol,2008,22(12):2596-2608.
|
[33] |
OLIVECRONA G.Role of lipoprotein lipase in lipid metabolism[J].Curr Opin Lipidol,2016,27(3):233-241.
|
[34] |
DE SÁ MOTA P,RICHARD A J,HANG H,et al.Transcriptional regulation of adipogenesis[J].Compr Physiol,2017,7(2): 635-674.
|
[35] |
TANG Q Q,LANE M D.Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation[J].Genes Dev,1999,13(17):2231-2241.
|
[36] |
TONTONOZ P,HU E D,SPIEGELMAN B M.Stimulation of adipogenesis in fibroblasts by PPARγ2,a lipid-activated transcription factor[J].Cell,1994,79(7):1147-1156.
|
[37] |
ZHANG F J,PAN T L,NIELSEN L D,et al.Lipogenesis in fetal rat lung:importance of C/EBPα,SREBP-1c,and stearoyl-CoA desaturase[J].Am J Respir Cell Mol Biol,2004,30(2):174-183.
|
[38] |
赵莉鸽.NR4A1过表达对APP代谢和Tau磷酸化影响的研究[D].重庆:重庆医科大学,2017.ZHAO L G.The effect of NR4A1 overexpression on APP metabolismand Tau phosphorylation[D].Chongqing:Chongqing Medical University,2017.(in Chinese)
|
[39] |
ZHOU H,WANG J,ZHU P J,et al.NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α[J].Basic Res Cardiol,2018,113(4): 23.
|
[40] |
ZHANG Z W,YU J B.NR4A1 promotes cerebral ischemia reperfusion injury by repressing Mfn2-mediated mitophagy and inactivating the MAPK-ERK-CREB signaling pathway[J].Neurochem Res,2018,43(10):1963-1977.
|
[41] |
YAN H Z,XIAO F,ZOU J,et al.NR4A1-induced increase in the sensitivity of a human gastric cancer line to TNFα-mediated apoptosis is associated with the inhibition of JNK/Parkin-dependent mitophagy[J].Int J Oncol,2018,52(2):367-378.
|