环状RNA及其在生殖发育中的研究进展

doi:10.11843/j.issn.0366-6964.2020.09.001

摘要/Abstract

摘要： 环状RNA（circular RNA，circ-RNA）是一类由初始转录RNA反向剪接，形成的闭合环状RNA分子，广泛存在于真核细胞中。因不受RNA外切酶切割，所以稳定存在时间长。主要通过海绵吸附作用竞争性结合miRNA调节基因表达。circ-RNA分子鉴定及其生理调控作用成为近几年生命科学领域的研究热点，本文从circ-RNA的生成过程、在早期胚胎发育调控以及配子发育过程中的数量和作用等方面进行了综述。

关键词: 环状RNA, 生成过程, 生殖发育, 基因表达

Abstract: Circular RNA (circ-RNA) is a class of closed circular RNA molecules formed by reverse splicing of the initial transcriptional RNA, which are expressed abundantly in eukaryocytic cells. circ-RNA exists stably for a long period because of the resistance to RNA exonuclease. The expression of genes is regulated by cornpetitive binding of miRNA via sponge absorption. Recent studies demonstrated that circ-RNA molecular identification and physiological regulation had become the focus of life science research. In this review, we summarized the biogenesis of circ-RNA, the role in regulating early embryonic development, and the quantity and effects during the gamete development.

Key words: circ-RNA, formation, reproductive development, gene expression

中图分类号:

S813.1

陈慧芳, 杨天浩, 蔡健锋, 李超, 白银山. 环状RNA及其在生殖发育中的研究进展[J]. 畜牧兽医学报, 2020, 51(9): 2039-2047.

CHEN Huifang, YANG Tianhao, CAI Jianfeng, LI Chao, BAI Yinshan. Circular RNA and Its Research Progress in Reproductive Development[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(9): 2039-2047.

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