营养物质对动物内源性宿主防御肽表达的调节作用

doi:10.11843/j.issn.0366-6964.2020.08.001

摘要/Abstract

摘要： 宿主防御肽是动物体产生的一种多功能肽，不仅具有广谱的抗菌功能，还可作为先天性免疫调节因子，有效增强动物机体免疫力，阻止病原微生物的侵扰，对保证动物健康具有重要意义。宿主防御肽在动物体内的表达受到日粮中各种营养物质的调控，有研究者认为，以营养调控的方式促进宿主内源防御肽的表达有益于动物健康和生产性能的提高，是未来实现无抗、健康养殖的可能策略之一。本文综合论述了动物饲粮中多种营养物质对宿主内源防御肽表达的调控作用，为评价营养物质调节宿主免疫和对动物健康及生产的影响提供新的理论参考。

关键词: 宿主防御肽, 外源营养素, 表达调控

Abstract: Host defense peptide is a multifunctional peptide produced by animals. It not only has broad-spectrum antimicrobial function, but also can be used as an innate immune regulator to enhance the body immunity and prevent the invasion of pathogenic microorganisms. It plays an significant role in ensuring animal health. The expression of host defense peptide is regulated by various nutrients in the diet. Some researchers suggested that promoting the expression of host endogenous defense peptide by nutritional regulation was beneficial to the improvement of animal health and production performance, and was one of the possible strategies to achieve antibiotic-free and healthy breeding in the future. In this review, the regulation of endogenous defense peptide expression by various nutrients is discussed comprehensively, which will provide a new theoretical reference for evaluating the effects of nutrients on host immunity and animal health and production.

Key words: host defense peptide, endogenous nutrients, express regulation

中图分类号:

S852.4

陈永宏, 罗芳, 陶金忠, 王晶. 营养物质对动物内源性宿主防御肽表达的调节作用[J]. 畜牧兽医学报, 2020, 51(8): 1775-1783.

CHEN Yonghong, LUO Fang, TAO Jinzhong, WANG Jing. Regulation of Nutrients on the Expression of Endogenous Host Defense Peptide in Animals[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(8): 1775-1783.

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