阿苯达唑固体分散体的制备及分析

doi:10.11843/j.issn.0366-6964.2014.06.022

畜牧兽医学报 ›› 2014, Vol. 45 ›› Issue (6): 1018-1023.doi: 10.11843/j.issn.0366-6964.2014.06.022

阿苯达唑固体分散体的制备及分析

董春柳，刘艳艳，王天梓，佟恒敏，李艳华^*

(东北农业大学动物医学学院动物药学教研室，哈尔滨 150030)

收稿日期:2013-10-29 出版日期:2014-06-23 发布日期:2014-06-23
通讯作者: 李艳华，教授，博士生导师，主要从事病原微生物耐药性的研究与新兽药的研发，E-mail:liyanhua1970@163.com
作者简介:董春柳(1991-)，女，黑龙江明水人，硕士生，主要从事新兽药的研发研究，E-mail：dcliu2011@163.com
基金资助:
东北农业大学动物普通疾病防治重点实验室（120105）

Preparation and Analysis of Albendazole Solid Dispersions

DONG Chun-liu，LIU Yan-yan，WANG Tian-zi，TONG Heng-min，LI Yan-hua^*

(Department of Animal Pharmacy，College of Veterinary Medicine，Northeast Agricultural University，Harbin 150030，China)

Received:2013-10-29 Online:2014-06-23 Published:2014-06-23

摘要/Abstract

摘要：

以聚乙二醇6000和泊洛沙姆188(PEG6000∶P188=1∶2)为联合载体，通过熔融法制备阿苯达唑固体分散体。当阿苯达唑与联合载体的比例为1∶5时，通过相溶解度试验和体外溶出度的测定，评价该固体分散体的溶出特性。通过X-射线衍射法、红外光谱法及扫描电镜方法对固体分散体进行物相鉴定。结果表明，PEG6000和P188作为联合载体制备阿苯达唑固体分散体时，能显著提高阿苯达唑的体外溶出度，达90.48%。物相鉴定显示，联合载体和药物之间未发生化学反应，固体分散体以非晶型态存在。综上，选出PEG6000和P188比例为1∶2作为联合载体，利用熔融法制备固体分散体能显著提高阿苯达唑的体外溶出度，且制备方法简单。

Abstract:

Solid dispersions of albendazole were prepared by melt technique using polyethylene glycol 6000 (PEG6000) and poloxamer 188 (P188) in combination (1∶2).When the ratio of albendazole (ABZ) and combined carrier was 1∶5，the dissolution characteristics of solid dispersion were evaluated through measuring the phase solubility studies and dissolution studies.The solid dispersion was investigated using X-ray diffraction analysis，Fourier-transform infrared spectroscopy and scanning electron microscopy.The results showed that PEG6000 and P188 were recognised as a better combined carrier when preparing solid dispersion of albendazole，and can significantly improve the in vitro dissolution rate to 90.48%.No chemical interaction was found between ABZ and combined carrier，and solid dispersion pattern is amorphous shape.These results indicated that as a combined carrier，the proper ratio of elected PEG6000 to P188 was 1 to 2，and preparation by melt technique for solid dispersion can significantly improve the dissolution of ABZ，and the preparation is simple.

中图分类号:

董春柳，刘艳艳，王天梓，佟恒敏，李艳华. 阿苯达唑固体分散体的制备及分析[J]. 畜牧兽医学报, 2014, 45(6): 1018-1023.

DONG Chun-liu，LIU Yan-yan，WANG Tian-zi，TONG Heng-min，LI Yan-hua. Preparation and Analysis of Albendazole Solid Dispersions[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(6): 1018-1023.

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阿苯达唑固体分散体的制备及分析

Preparation and Analysis of Albendazole Solid Dispersions

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