禽霍乱新型疫苗的研究进展

doi:10.11843/j.issn.0366-6964.2018.11.003

Abstract

Abstract:

Fowl cholera is a contagious and systemic disease of poultry worldwide caused by the species Pasteurella multocida, causing high morbidity and mortality and severe economic losses to poultry industry. As the prevalence of multidrug resistance among Pasteurella multocida isolates has continuously increased, immunization methods, the most potent preventive measure should become the main tool for controlling the disease. The current commercial vaccines contain traditional inactivated vaccine and empirically derived live vaccines, however, they exhibit some defects. The former provides limited cross-protection against heterologous serotypes; genetic background of the latter is not known and reversion to virulence occurs. Thus, novel vaccines against fowl cholera are urgently required. Here, we summarized the development of a variety of new-type vaccines against fowl cholera including attenuated live vaccine, subunit vaccine and DNA vaccine, to promote the exploration of new vaccines with safety and effective protection.

Key words: Pasteurella multocida, fowl cholera, vaccines

CLC Number:

S852.612

LIANG Sheng, ZHAO Xin-xin, CHENG An-chun. Progress in Development of New-type Vaccines against Fowl Cholera[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(11): 2317-2325.

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Progress in Development of New-type Vaccines against Fowl Cholera

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