Technical Strategies of Animal Embryo Breeding and Its Application
LI Yan-he 1，LIU Jun 1，2，3，ZHANG Yong 1，2，3，QUAN Fu-sheng 1，2，3*
（1.College of Veterinary Medicine，Northwest A&F University，Yangling 712100，China；2.Key Laboratory of Animal Biotechnology，Ministry of Agriculture，Yangling 712100，China；3.Animal Embryo Engineering Technology Research Center of Shaanxi Province，Yangling 712100，China）
LI Yan-he，LIU Jun，ZHANG Yong，QUAN Fu-sheng. Technical Strategies of Animal Embryo Breeding and Its Application[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(10): 1954-1960.
［1］WU B.New discoveries in embryology［M］.Licensee in Tech，2015.http：//dx.doi.org/10.5772/61299.
［2］WILMUT I，SCHNIEKE A E，MCWHIR J，et al.Viable offspring derived from fetal and adult mammalian cells［J］.Nature，1997，385(6619)：810-813.
［3］YIN H，XUE W，CHEN S，et al.Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype［J］.Nat Biotechnol，2014，32：551-553.
［4］LIU X，WANG Y，GUO W，et al.Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows［J］.Nat Commun，2013，4：2565.
［5］WU H，WANG Y，ZHANG Y，et al.TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis［J］.Proc Natl Acad Sci U S A，2014，112(13)：1530-1539.
［6］YU Y，WANG Y，TONG Q，et al.A site-specific recombinase-based method to produce antibiotic selectable marker free transgenic cattle［J］.PLoS One，2013，8(5)：62457.
［7］LAI L，KANG J X，LI B，et al.Generation of cloned transgenic pigs rich in omega-3 fatty acids［J］. Nat Biotechnol，2006，24：435-436.
［8］BETTERIDGE K J.Farm animal embryo technologies：Achievements and perspectives［J］.Theriogenology，2006，65：905-913.
［9］GREGER M.Transgenesis in animal agriculture：addressing animal health and welfare concerns［J］.Agric Environ Ethics，2011，24：451-472.
［10］WU B，ZAN L.Enhance beef cattle improvement by embryo biotechnologies［J］.Reprod Dom Anim，2012，47：865-871.
［11］MAPLETOFT R J.Perspectives on bovine embryo transfer［J］.WCDS Adv Dairy Technol，2012，24：83-93.
［12］HAYES B J，LEWIN H A，GODDARD M E.The future of livestock breeding：genomic selection for efficiency，reduced emissions intensity，and adaptation［J］.Trends Genet，2013，29(4)：206-214.
［13］IBANEZ-ESCRICHE N，FORNI S，NOGUERA J L，et al.Genomic information in pig breeding：Science meets industry needs［J］.Livest Sci，2014(166)：94-100.
［14］HOSSEIN-ZADEH N G.Evaluation of the genetic trend of milk yield in the multiple ovulation and embryo transfer populations of dairy cows，using stochastic simulation［J］.C RBiol，2010(333)：710-715.
［15］PRESICC G A，XU J，GONG G C，et al.Oocyte source and hormonal stimulation for in vitro fertilization using sexed spermatozoa in cattle［J］.Vet Med Int，2011：145626.
［16］DAIRY S J，MEUWISSEN T H.Optimizing pure line breeding strategies utilizing reproductive technologies［J］. J Dairy Sci，1998，81(2)：47-54.
［17］LUO W，WANG Y，ZHANG Y.Simulation study on the efficiencies of MOET nucleus breeding schemes applying marker assisted selection in dairy cattle［J］. Sci China Ser C，2009，52(3)：296-306.
［18］STRANDEN I，MAKI T A，MANTYSAARI E A.Genetic progress and rate of inbreeding in a closed adult MOET nucleus under different mating strategies and heritabilities［J］.J Dairy Sci，1991，108(6)：401-411.
［19］HORTON B.Optimal structure for a three-tiered co-operative sheep breeding system using AI and MOET［J］. Proc Aut Assn Anim Breed Genet，1992，10：435-439.
［20］WILSON D E，MORRICAL D G.The national sheep improvement program：a review［J］.J Anim Sci，1991，69(9)：3872-3881.
［21］NORTHCUTT S L，WILLHAM R L，WILSON D E.Genetic parameters for nuclear and nonnuclear inheritance in three synthetic lines of beef cattle differing in mature size［J］.JAnim Sci，1991，69(12)：4745-4753.
［22］TIAN X C，KUBOTA C，SAKASHITA K，et al.Meat and milk composition of bovine clones［J］.Proc Natl Acad Sci U S A， 2005，102：6261-6266.
［23］YANG X，TIAN X C，KUBOTA C，et al.Risk assessment of meat and milk from cloned animals［J］.Nat Biotechnol，2007，25(1)：77-83.
［24］MAPLETOFT R J，HASLER J F.Assisted reproductive technologies in cattle：a review［J］.Rev Sci Tech，2005，24(1)：393-403.
［25］HANS D D，AURÉLIEN C，HUBERT P，et al.Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle［J］.Nat Genet，2014，46(8)：858-865.
［26］DAIRY S J，MEUWISSEN T H.Optimizing pure line breeding strategies utilizing reproductive technologies［J］. J Dairy Sci，1998，81(2)：47-54.
［27］LUO W，WANG Y，ZHANG Y.Simulation study on the efficiencies of MOET nucleus breeding schemes applying marker assisted selection in dairy cattle［J］. Sci China C LifeSci，2009，52(3)：296-306.
［28］BAUER J，PRˇIBYL J，VOSTRY L.Short communication：Reliability of single-step genomic BLUP breeding values by multi-trait test-day model analysis［J］.J Dairy Sci，2015，98(7)：4999-5003.
［29］SU G，MADSEN P，NIELSEN U S，et al.Genomic prediction for Nordic Red cattle using one-step and selection index blending［J］.J Dairy Sci，2012，95(2)：909-917.
［30］HORTON B J，BANKS R G.Industry benefits from using genomic information in two-and three-tier sheep breeding systems［J］.Anim Prod Sci，2015，55(4)：437-446.
［31］张立.牛羊胚胎工程技术产业化研究与应用［D］.杨凌：西北农林科技大学，2005.
ZHANG L.Research and application for industrialization of embryo engineering technology in cattle and sheep［D］.Yangling：Northwest A&F University，2005.(in Chinese)
［32］刘俊平.胚胎工程技术在奶牛繁育中应用的研究［D］.杨凌：西北农林科技大学，2005.
LIU J P.Study on application of embryo engineering technology for reproduction of dairy cows［D］.Yangling：Northwest A&F University，2005.(in Chinese)
［33］权富生.山羊和绵羊超数排卵及规模化胚胎移植技术研究［D］.杨凌：西北农林科技大学，2010.
QUAN F S.Superovulation and large-scale transfer embryo in goats and sheep［D］.Yangling：Northwest A&F University，2010.(in Chinese)
［34］PARAMIO M T.In vivo and in vitro embryo production in goats［J］.Small Ruminant Res，2010，89：144-148.
［35］ZHANG Z P，ZHANG Y，LIU J P，et al.Codeposition of dNTPs detection for rapid LAMP-based sexing of bovine embryos［J］.Reprod Domest Anim，2009，44：116-121.
［36］VLECK L D.Implications of cloning for breed improvement strategies：are traditional methods of animal improvement obsolete?［J］. J Anim Sci，1999，2(1)：111-121.
［37］QUAN F S，ZHANG Z P，AN Z X，et al.Multiple factors affecting superovulation in poll dorset in China［J］.Reprod Domest Anim，2011，46：39-44.
［38］QUAN F S，ZHANG Z P，AN Z X，et al.Effect of transporting donor or recipient does and their embryos on the outcome of fresh embryo transfer in Boer goats［J］.Small Ruminant Res，2010，88：1-5.
［39］GUO J T，AN Z X，YU L，et al.Cloned goats (Capra hircus) from adult ear cells［J］.Sci China Ser C，2002，45：260-267.
［40］WEDEKIND D，WEISS H，JÖRNS A，et al.Effects of polyinosinic-polycytidylic acid and adoptive transfer of immune cells in the Lew.1AR1-iddm rat and in its coisogenic Lew.1AR1 background strain［J］.Autoimmunity，2005，38(4)：265-275.
［41］LIU X，WANG Y，TIAN Y，et al.Generation of mastitis resistance in cows by targeting human lysozyme gene to β-casein locus using zinc-finger nucleases［J］. Proc R Soc B，2014，281：20133368.
［42］WANG H，YANG H，SHIVALILA C S，et al.One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering［J］. Cell，2013，153(4)：910-918.
［43］ZHOU J，SHEN B，ZHANG W，et al.One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering［J］.Int J BiochemCell B，2014，46：49-55.
［44］YANG H，WANG H，SHIVALILA C S，et al.One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering［J］.Cell，2013，154：1370-1379.
［45］SONG J，HUA S，SONG K，et al.Culture，characteristics and chromosome complement of Siberian tiger fibroblasts for nuclear transfer［J］.In vitro Cell Dev Biol Anim，2007，43：203-209.
［46］WELLS D N，MISICA P M，TERVIT H R.Adult somatic cell nuclear transfer is used to preserve the last surviving cow of the Enderly Island cattle breed［J］.Reprod Fert Dev，1998，3：69-78.
［47］LANZA R P，CIBELLI J B，DIAZ F.Cloning of an Endangered species (Bos gaurus) using interspecies nuclear transfer cloning［J］.Cloning，2000(2)：79-90.
［48］PAIVA S R，FACÓ O，FARIA D A，et al.Molecular and pedigree analysis applied to conservation of animal genetic resources：the case of Brazilian Somali hair sheep［J］.Trop Anim Health Pro，2011，43(7)：1449-1457.
［49］MARAA L，CASUB S A，CARTAC M D.Cryobanking of farm animal gametes and embryos as a means of conserving livestock genetics［J］. Anim Reprod Sci，2013，138：25-38.
［50］KARST S，STRUCKEN E M，SCHMITT A O，et al.Effect of the myostatin locus on muscle mass and intramuscular fat content in a cross between mouse lines selected for hypermuscularity［J］.BMC Genom，2013，14：1-16.
［51］LONG Y，RUAN G R，SU Y，et al.Genome-wide association study identifies QTLs for EBV of backfat thickness and average daily gain in Duroc pigs［J］. Russ J Genet，2014，50：1308-1315.
［52］DONG Q，LIU H Y，LI X Y，et al.A genome-wide association study of five meat quality traits in Yorkshire pigs［J］.Front Agric Sci，2014，1(2)：137-143.
