ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2012, Vol. 43 ›› Issue (7): 1042-1048.doi:

• 遗传繁育 • Previous Articles     Next Articles

Developmental Changes of Ghrelinimmunopositive Cells in the Gastrointestinal Tract of Goat

ZHANG Demin1,2, WANG Shuying1，2*, YIN Yutao1,2, LIU Xiao1,2,

HOU Yanmeng1,2, HUANG Libo1,2, ZHANG Chunlan3

  

  1. 1. College of Animal Science and Technology, Shandong Agricultural University, Tai’an 271018, China; 2. Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai’an 271018, China; 3. Shandong Animal Husbandry Group, Jinan 250022, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2012-07-27 Published:2012-07-27
  • Contact: WANG Shuying1

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Abstract:

In the present study, the distribution, morphological characteristics and developmental changes of Ghrelinimmunopositive (Ghrelinip) cells in the gastrointestinal tract of goat were investigated. Using the method of immunohistochemistry, Ghrelinip cells were showed in the gastrointestinal tract of Jining Gray goat at the ages of day 0,30,60,90,120,150 and 180. Ghrelinip cells classified into open and closedtype cells were found to be localized in the mucosa epithelium, glands and lamina propria of abomasums, duodenum, jejunum, ileum, cecum and colon, but not in rumen, reticulum, omasum and rectum. The greatest number of Ghrelinip cells was found in the abomasums and the Ghrelinip cell density gradually decreased from the abomasums to the colon. The percentage of closedtype cells to all immunopositive cells also decreased from the abomasums to the colon. With the goat growth, the densities of Ghrelinip cells in the abomasums and jejunum increased from ages of day 0 to 120, but slightly decreased at ages of day 150 and 180. There was also a steady increase in the number of Ghrelinip cells from postnatal day 0 to 90 in duodenum, which reached a peak and remained steady. Very few Ghrelinip cells were found in the ileum, cecum and colon, and the densities increased with the age growth. The change of Ghrelinimmunopositive cells in the gastrointestinal tract of growing goats suggests that Ghrelin may be involved in gastrointestinal tract development.