ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2012, Vol. 43 ›› Issue (7): 1015-1019.doi:

• 遗传繁育 • Previous Articles     Next Articles

Association of Polymorphisms of Porcine Protein Tyrosine Phosphatese 1B Gene Intron 7 with Fat Deposition Traits

WANG Lixia1,2，WEI Jintao3，RAN Zhiping2，QIAN Yunguo2，YU Ting2， XIONG Yuanzhu1*   

  1. 1.Key Laboratory of Pig Genetics and Breeding of Ministry of Agriculture，Huazhong Agricultural University，Wuhan 430070, China； 2. Institute of Animal and Veterinary Science， Wuhan Academy of Agricultural Science and Technology, Wuhan 430065， China； 3. Institute of Animal Husbandry and Veterinary, Hubei Academy of Agriculture Science，Wuhan 430064， China
  • Received:1900-01-01 Revised:1900-01-01 Online:2012-07-27 Published:2012-07-27
  • Contact: XIONG Yuanzhu

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Abstract:

To discuss the association of polymorphism of porcine protein tyrosine phosphatese 1B gene with fat deposition traits, in this study, the sequence of intron 7 of the porcine PTP1B gene was obtained from Large White, Landrace and Meishan pigs. Sequence comparison revealed a G／A mutation which was detected by PCREco88 IRFLP. The allele distribution revealed that Large White and Landrace pigs had only A allele, and GA was preponderant genotype in Meishan pigs. Association analysis between the polymorphism of PTP1B gene and fat deposition traits was performed in 213 Large White × Meishan F2 pigs. Significant associations of the genotypes with fat deposition traits such as leaf fat weight (LFW), internal fat rate (IFR) and thoraxwaist fat thickness were found. The individuals with GA genotype had lowest leaf fat weight and internal fat rate than the individuals with the other genotypes ( GA＜GG＜AA), this might be reflection of heterosis. The individuals with GG genotype had lowest thoraxwaist fat thickness than the individuals with the other genotypes (GG＜GA＜AA). These results indicate that allele G is significantly associated with the decreasing of fat deposition, the polymorphic site can be used as the candidate site affecting pig fat deposition traits.