猪红细胞生成素受体基因突变与血常规性状关联分析

Abstract

Abstract: The aim of present study was to investigate the effect of porcine erythropoietin receptor (EPOR) gene on blood parameters. Six blood parameters, hematocrit (HCT), hemoglobin (HGB), mean corpuscular hemoglobin (MCH), mean cell volume (MCV), red blood cell count (RBC) and red blood cell distribution width (RDW), were measured in Large White × Minzhu intercross porcine population. EPOR was genotyped using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF). The associations of g.705G>T in intron 1 and g.2373C>T in intron 4 with the six blood parameters were analyzed. The result showed that the SNP at g.705G>T was not significantly associated with any trait. Two genotypes (CC and CT) of SNP at g.2373C>T were found in this population. The HCT of individuals with CT genotype was higher than that of individuals with CC genotype (P<0.05), while this SNP was not significant associated with other five traits. These results indicate that the mutation of EPOR gene can affect the HCT and this gene can be a potential candidate gene for immunity relate traits (e.g. HCT) for further study.

CLC Number:

S828
S813.3

SONG Xin, CAO Sui-zhong, ZHANG Long-chao,et al. Association of SNPs in Erythropoietin Receptor Gene with Blood Parameters[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, doi: .

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Association of SNPs in Erythropoietin Receptor Gene with Blood Parameters

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