ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2011, Vol. 42 ›› Issue (4): 562-566.doi:

• 基础兽医 • Previous Articles     Next Articles

The Effects of Bacillus subtilis on Local Innate Immune and Expressionof TLR of Pigs

LI Yun-feng, DENG Jun, ZHANG Jin-hua, YANG Qian*   

  1. Key Laboratory of Animal Physiology and Biochemistry of Ministry of Agriculture,College of Animal Medicine, Nanjing Agricultural University, Nanjing 210095, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2011-04-20 Published:2011-04-20

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Abstract: This experiment was conducted to study the effects of Bacillus subtilis on small intestine local mucosal immune responses and the expression of TLRs of pigs. The newborn piglets were orally administrated with Bacillus subtilis at 0, 7, 14, and 26 d after birth.The results showed that Bacillus subtilis could significantly promote the expression of TLR 9 and cytokine IL-6 in duodenum (P<0.05) and increase the quantity of IgA excreting cells (P<0.01), as well as increasing the expression of IL-1 in ileum (P<0.01)The results implied that Bacillus subtilis may increase the expression of IL-6 and the quantity of IgA excreting cells through interact with TLR 9. Orally administrated with Bacillus subtilis to prevent the newborn piglet diarrhea is promising.