ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2010, Vol. 41 ›› Issue (6): 755-760.doi:

• 基础兽医 • Previous Articles     Next Articles

Changes of Cytokines in Immune Organs of Chickens Infected with H5N1 Avian Influenza Virus

ZHENG Shi-min1, GAO Xue-li1, LIU Chao-nan1, LIU Ming2   

  1. 1. College of Veterinary Medicine, Northeast Agricultural University，Harbin 150030，China；2. Harbin Veterinary Research Institute，Chinese Academy of Agricultural Sciences，Harbin 150001，China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-06-25 Published:2010-06-25

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Abstract: The aim of the present study was to investigate role of cytokines in avian influence immune pathogenesis, technology of cell culture and cytokines activity detection was used to research the dynamic changes of inductive activity of interleukin-2 (IL-2), interferon (IFN) and tumor necrosis factor (TNF) in thymus and spleen of SPF chickens infected with H5N1 avian influenza virus（AIV）at 7 and 21 days old. The results showed that: IL-2 and IFN inductive activity of T-lymphocytes in thymus and spleen of SPF chickens infected with AIV were decreased compared with that of control, but TNF inductive activity from spleen of SPF chickens infected with AIV was increased compared with that of control. The results indicated that above-mentioned cytokines played a very important regulation role in immune pathogenesis of avian influenza.