ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2006, Vol. 37 ›› Issue (10): 1027-1035.doi:

• 预防兽医 • Previous Articles     Next Articles

Molecular Characterization of Footandmouth Disease Virus O/LZ

MA Ming-xiao;JIN Ning-yi;LI Chang;LIU Hui-juan;ZHENG Min;JIN Ming-lan;JIA Lei-li;ZHANG Lin;LU Hui-jun;SHEN Guo-shun;WANG Rui-lin;JIN Kuo-shi   

  1. 1.Laboratory of Gentic Engineering Institute, Military Veterinary Academy of Military Medical Sciences,PLA, Changchun 130062,China; 2. College of Animal Science and Veterinary Medicine,Jinzhou Medical University,Jinzhou 121001,China;3.Agricultural Division, Jilin University ,Changchun 136002,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-10-25 Published:2006-10-25

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Abstract: The genome of FootandMouth disease virus (FMDV) O/LZ isolate was cloned by RT-PCR, and sequenced. The result showed that the genome of O/LZ isolate is 8 014nt in length, including partical 5′UTR and complete polyprotein coding region, and their nucleotide sequence are 1 042 nt and 6 969nt respectively. Comparison between O/LZ and other reference isolates indicates that O/LZ strain have a close evolutionary relationship with O/HNK/2002, O/ES/2001,O/CHP/TW/97,etc,O/LZ should be classified to Cathay topotype . Furthermore, comparison of deduced amino acid residues at the antigenic sites with PanAsia strain of FMDV serotype O ME-SA topotype shows there are obviously topotypical amino acid difference at Site 1 and Site 3, thus, suggesting the less antigenic relationships between these two topotype isolates.