ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2005, Vol. 36 ›› Issue (5): 517-520.doi:

• 研究简报 • Previous Articles    

Effects of Pentoxifylline, Radix Scutellariae and Rhizoma Atractylodis on LPS-induced Abortion and Uterine IL-10 Contents in Mice

ZHONG Xiu-hui; SHI Wan-yu; GONG Xin-cheng;ZHAI Xiang-he;ZHANG Tie;
LI Shao-hua;CHU Su-min
  

  1. College of Animal Science and Technology, Agricultural University of Hebei,Baoding 071001,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2005-05-25 Published:2005-05-25

PDF (PC)

692

Abstract: Lipopolysaccharide (LPS) was injected via the tail vein (0.1 μg per mouse) to induce abortion (embryo resorption) in Kunming mice. The interleukin 10 (IL-10) contents in the uterus was assayed by ELISA. The results revealed that the IL-10 level was significantly decreased in the LPS-induced abortion group of mice compared with the controls. Use of pentoxifylline, or a combination of Radix scutellariae and Rhizoma atractylodis reversed the LPS effects: bringing down the fetal resorption rate, and enhancing the IL-10 level significantly. The study indicates that the anti-abortive effects of PXF and the combination of Radix scutellariae and Rhizoma atractylodis are closely related to up-regulation of the Th2 cytokine IL-10 at the maternal fetal interface.