多黏菌素耐药基因的变异特征及传播规律的研究现状

doi:10.11843/j.issn.0366-6964.2018.10.006

Abstract

Abstract:

Since the discovery of mcr-1 plasmid-mediated colistin resistance gene from China in 2015, colistin resistant genes are divided into 5 categories according to reports, including mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5. The researchers need to know the characteristic and the dissemination to provide reference for prevention and control measures in future. For this reason, we summarized the literature and found:1) The differences in nucleotides and amino acids sequence from mcr-1 to mcr-5 are notable, the origin of these resistance genes is different, such as MCR-5 (the protein encoded by mcr-5) is distinct from MCR-1, MCR-2, MCR-3, MCR-4 with protein sequence identity of 36.11% (MCR-1), 35.29% (MCR-2), 34.72% (MCR-3) and 33.71% (MCR-4), respectively. 2) Many variant subtypes:Except for mcr-5, all other 4 kinds of gene type have several subtypes, such as there are more than ten subtypes of mcr-1 and mcr-3. 3) The common coexistence with other resistant genes greatly increases the probability of multidrug resistance. 4) Spread widely:it has been widely spread in more than 40 countries and 5 continents. In conclusion, colistin resistance genes mediated by plasmid have the characteristics of rapid mutation, complex type, widely spread, and generally coexist with a variety of other antibiotic resistance genes, once a large-scale outbreak of multidrug resistant pathogenic bacteria carrying this gene will greatly threaten the health of human being and animals, supervision and control should be strengthened.

CLC Number:

Q931
R378

SUN He, ZHANG Ya-chao, SHANGGUAN Zhen-kun, ZHANG Yi, FAN Ruo-lan, LI Hang, GUAN Song-lei, ZHANG Lin-bo. Research Progress on the Variation Characteristic and Dissemination of Colistin Resistance Genes[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(10): 2102-2111.

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Research Progress on the Variation Characteristic and Dissemination of Colistin Resistance Genes

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