骨骼肌卫星细胞增殖与成肌分化过程中关键信号通路的作用

doi:10.11843/j.issn.0366-6964.2017.11.001

Abstract

Abstract:

Skeletal muscle satellite cells are considered to be the only stem cell source of adult skeletal muscle cells differentiation. It is generally in resting state. After stimulated, skeletal muscle satellite cells can be activated, proliferation and differentiation into muscle cells through the key signaling pathway, then participate in the formation of skeletal muscle and injury repair. Signaling pathways commonly involve in the process of proliferation and differentiation of skeletal muscle satellite cells.Such as Wnt and mTOR signaling pathways regulate satellite cell activity through cascade amplification, Notch and P38 MAPK signaling pathways are thought to be closely related to the resting state of satellite cells, JAK/STAT signaling pathway can cause different specific responses of satellite cells at different stages. These signaling pathways are linked to each other, and thus affect the growth and repair capacity of skeletal muscle satellite cells. In this paper, we reviewed the study progress of the effects of Wnt, Notch, P38 MAPK, mTOR, JAK/STAT signaling pathways on the proliferation and differentiation of skeletal muscle satellite cells, and laid a foundation for further study on the molecular mechanism of skeletal muscle formation and muscular development.

CLC Number:

S811.3

ZHENG Qi, SUI Meng-hua, LING Ying-hui. The Role of Key Signaling Pathways in the Proliferation and Differentiation of Skeletal Muscle Satellite Cells[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(11): 2005-2014.

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References

[1] 何波, 郑嵘, 熊远著, 等. 新生猪骨骼肌卫星细胞的培养鉴定及生物学特性[J]. 畜牧兽医学报, 2006, 37(6):555-559.
HE B, ZHENG R, XIONG Y Z, et al. Culture, identification and biological characteristics of skeletal muscle satellite cells of the neonatal pig[J]. Acta Veterinaria et Zootechnica Sinica, 2006, 37(6):555-559. (in Chinese)
[2] CHANG N C, RUDNICKI M A. Satellite cells:the architects of skeletal muscle[J]. Curr Top Dev Biol, 2014, 107:161-181.
[3] 沈林園, 张顺华, 吴泽辉, 等. 骨骼肌卫星细胞对肉品质的影响及其分化调控[J]. 遗传, 2013, 35(9):1081-1086.
SHEN L Y, ZHANG S H, WU Z H, et al. The influence of satellite cells on meat quality and its differential regulation[J]. Hereditas (Beijing), 2013, 35(9):1081-1086. (in Chinese)
[4] SHELTON M, METZ J, LIU J, et al. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells[J]. Stem Cell Rep, 2014, 3(6):1159.
[5] SOLEIMANI V D, PUNCH V G, KAWABE Y I, et al. Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs[J]. Dev Cell, 2012, 22(6):1208-1220.
[6] WANG C, WANG M, ARRINGTON J, et al. Ascl2 inhibits myogenesis by antagonizing the transcriptional activity of myogenic regulatory factors[J]. Development, 2017, 144(2):235-347.
[7] HWANG J, LEE S J, YOO M, et al. Kazinol-P from Broussonetia kazinoki, enhances skeletal muscle differentiation via p38MAPK and MyoD[J]. Biochem Biophys Res Commun, 2015, 456(1):471-475.
[8] WEBSTER M T, MANOR U, LIPPINCOTT-SCHWARTZ J, et al. Intravital imaging reveals ghost fibers as architectural units guiding myogenic progenitors during regeneration[J]. Cell Stem Cell, 2016, 18(2):243-252.
[9] GÜNTHER S, KIM J, KOSTIN S, et al. Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells[J]. Cell Stem Cell, 2013, 13(5):590-601.
[10] RUDNICKI M A, LE GRAND F, MCKINNELL I, et al. The molecular regulation of muscle stem cell function[J]. Cold Spring Harb Sym Quant Biol, 2008, 73:323-331.
[11] COLLINS C A, OLSEN I, ZAMMIT P S, et al. Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche[J]. Cell, 2005, 122(2):289-301.
[12] GREENWALD I, KOVALL R. Notch signaling:genetics and structure[J]. WormBook, 2013,1(17):1-28.
[13] PREVIS R A, COLEMAN R L, HARRIS A L, et al. Molecular pathways:translational and therapeutic implications of the Notch signaling pathway in cancer[J]. Clin Cancer Res, 2015, 21(5):955-961.
[14] ZHANG K J, LU Q Y, NIU X Q, et al. Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression[J]. Acta Pharmacol Sin, 2009, 30(2):153-158.
[15] TSIVITSE S. Notch and Wnt signaling, physiological stimuli and postnatal myogenesis[J]. Int J Biol Sci, 2010, 6(3):268-281.
[16] WEN Y F, BI P P, LIU W Y, et al. Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells[J]. Cell Mol Biol, 2012, 32(12):2300-2311.
[17] BI P P, KUANG S H. Notch signaling as a novel regulator of metabolism[J]. Trends Endocrinol Metab, 2015, 26(5):248-255.
[18] YUE F, BI P P, WANG C, et al. Pten is necessary for the quiescence and maintenance of adult muscle stem cells[J]. Nat Commun, 2017, 8:14328.
[19] GOPINATH S D, WEBB A E, BRUNET A, et al. FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal[J]. Stem Cell Rep, 2014, 2(4):414-426.
[20] MOURIKIS P, GOPALAKRISHNAN S, SAMBASIVAN R, et al. Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells[J]. Development, 2012, 139(24):4536-4548.
[21] KIVELÄ R, SALMELA I, NGUYEN Y H, et al. The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation[J]. Nat Commun, 2016, 7:13124.
[22] SHAN T Z, ZHANG P P, XIONG Y, et al. Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts[J]. Int J Biochem Cell Biol, 2016, 76:31-38.
[23] CARLSON M E, HSU M, CONBOY I M. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells[J]. Nature, 2008, 454(7203):528-532.
[24] QIN L L, XU J, WU Z F, et al. Notch1-mediated signaling regulates proliferation of porcine satellite cells (PSCs)[J]. Cell Signal, 2013, 25(2):561-569.
[25] PASUT A, CHANG N C, GURRIARAN-RODRIGUEZ U, et al. Notch signaling rescues loss of satellite cells lacking Pax7 and promotes brown adipogenic differentiation[J]. Cell Rep, 2016, 16(2):333-343.
[26] BRACK A S, CONBOY I M, CONBOY M J, et al. A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis[J]. Cell Stem Cell, 2008, 2(1):50-59.
[27] FUJIMAKI S, HIDAKA R, ASASHIMA M, et al. Wnt protein-mediated satellite cell conversion in adult and aged mice following voluntary wheel running[J]. J Biol Chem, 2014, 289(11):7399-7412.
[28] CLEVERS H, NUSSE R. Wnt/β-catenin signaling and disease[J]. Cell, 2012, 149(6):1192-1205.
[29] 杨秋梅, 史新娥, 沈清武, 等. Wnt/β-catenin信号通路相关基因及MyHCs在猪骨骼肌发育中的表达规律[J]. 畜牧兽医学报, 2011, 42(12):1686-1695.
YANG Q M, SHI X E, SHEN Q W, et al. The expression pattern of Wnt/β-catenin signal pathway related genes and MyHCs during porcine skeletal muscle development[J]. Acta Veterinaria et Zootechnica Sinica, 2011, 42(12):1686-1695. (in Chinese)
[30] VON MALTZAHN J, CHANG N C, BENTZINGER C F, et al. Wnt signaling in myogenesis[J]. Trends Cell Biol, 2012, 22(11):602-609.
[31] TAJBAKHSH S, BORELLO U, VIVARELLI E, et al. Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5[J]. Development, 1998, 125(21):4155-4162.
[32] OTTO A, SCHMIDT C, LUKE G, et al. Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration[J]. J Cell Sci, 2008, 121(17):2939-2950.
[33] MURPHY M M, KEEFE A C, LAWSON J A, et al. Transiently active Wnt/β-catenin signaling is not required but must be silenced for stem cell function during muscle regeneration[J]. Stem Cell Rep, 2014, 3(3):475-488.
[34] RUDOLF A, SCHIRWIS E, GIORDANI L, et al. β-catenin activation in muscle progenitor cells regulates tissue repair[J]. Cell Rep, 2016, 15(6):1277-1290.
[35] HULIN J A, NGUYEN T D T, CUI S, et al. Barx2 and Pax7 regulate Axin2 expression in myoblasts by interaction with β-catenin and chromatin remodelling[J]. Stem Cells, 2016, 34(8):2169-2182.
[36] SHAN T Z, ZHANG P P, LIANG X R, et al. Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis[J]. Stem Cells, 2014, 32(11):2893-2907.
[37] 杨映娟. Wnt/β-catenin信号通路对猪肌卫星细胞增殖分化影响的初步研究[D]. 杨凌:西北农林科技大学, 2008.
YANG Y J. Primary research on the effects of Wnt/β-catenin signalling on pig satellite cells' proliferation and differentiation[D]. Yangling:Northwest A&F University,2008. (in Chinese)
[38] LE GRAND F, JONES A E, SEALE V, et al. Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells[J]. Cell Stem Cell, 2009, 4(6):535-547.
[39] VON MALTZAHN J, BENTZINGER C F, RUDNICKI M A. Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle[J]. Nat Cell Biol, 2012, 14(2):186-191.
[40] MA X M, BLENIS J. Molecular mechanisms of mTOR-mediated translational control[J]. Nat Rev Mol Cell Biol, 2009, 10(5):307-318.
[41] ZHANG P P, LIANG X R, SHAN T Z, et al. mTOR is necessary for proper satellite cell activity and skeletal muscle regeneration[J]. Biochem Biophys Res Commun, 2015, 463(1-2):102-108.
[42] TAKAYAMA K, KAWAKAMI Y, LAVASANI M, et al. mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging[J]. J Orthop Res, 2017, 35(7):1375-1382.
[43] WU H Q, REN Y, PAN W, et al. The mammalian target of rapamycin signaling pathway regulates myocyte enhancer factor-2C phosphorylation levels through integrin-linked kinase in goat skeletal muscle satellite cells[J]. Cell Biol Int, 2015, 39(11):1264-1273.
[44] XIANG X X, ZHAO J, XU G Y, et al. mTOR and the differentiation of mesenchymal stem cells[J]. Acta Biochim Biophys Sin, 2011, 43(7):501-510.
[45] SCHIAFFINO S, DYAR K A, CICILIOT S, et al. Mechanisms regulating skeletal muscle growth and atrophy[J]. FEBS J, 2013, 280(17):4294-4314.
[46] RODGERS J T, KING K Y, BRETT J O, et al. mTORC1 controls the adaptive transition of quiescent stem cells from G₀ to G_Alert[J]. Nature, 2014, 510(7505):393-396.
[47] 史新娥, 吴国芳, 宋子仪, 等. 阻断PI3K/AKT通路通过激活FoxO1抑制猪骨骼肌卫星细胞分化[J]. 中国农业科学, 2014, 47(1):154-160.
SHI X E, WU G F, SONG Z Y, et al. Inhibition of PI3K/AKT pathway suppressing porcine skeletal muscle sattelite differentiation through activation of FoxO1 transcription factor[J]. Scientia Agricultura Sinica, 2014, 47(1):154-160. (in Chinese)
[48] 吴海青. mTOR信号通路对山羊骨骼肌卫星细胞增殖及分化的影响[D]. 呼和浩特:内蒙古大学, 2015.
WU H Q. The effects of mammalian target of rapamycin signaling pathway on proliferation and differentiation of goat skeletal muscle satellite cells[D]. Hohhot:Inner Mongolia University,2015. (in Chinese)
[49] CHEN W Y, LIN C L, CHUANG J H, et al. Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation[J]. Sci Rep, 2017, 7:41159.
[50] SEGALÉS J, PERDIGUERO E, MUÑOZ-CÁNOVES P. Epigenetic control of adult skeletal muscle stem cell functions[J]. FEBS J, 2015, 282(9):1571-1588.
[51] CARGNELLO M, ROUX P P. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases[J]. Microbiol Mol Biol Rev, 2011, 75(1):50-83.
[52] ZARUBIN T, HAN J H. Activation and signaling of the p38 MAP Kinase pathway[J]. Cell Res, 2005, 15(1):11-18.
[53] PERDIGUERO E L, RUIZ-BONILLA V, SERRANO A L, et al. Genetic deficiency of p38α reveals its critical role in myoblast cell cycle exit:the p38α-JNK connection[J]. Cell Cycle, 2007, 6(11):1298-1303.
[54] CHARVILLE G W, CHEUNG T H, YOO B, et al. Ex vivo expansion and in vivo self-renewal of human muscle stem cells[J]. Stem Cell Rep, 2015, 5(4):621-632.
[55] TROY A, CADWALLADER A B, FEDOROV Y, et al. Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPK[J]. Cell Stem Cell, 2012, 11(4):541-553.
[56] HAUSBURG M A, DOLES J D, CLEMENT S L, et al. Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay[J]. eLife, 2015, 4:e03390.
[57] BRIEN P, PUGAZHENDHI D, WOODHOUSE S, et al. p38α MAPK regulates adult muscle stem cell fate by restricting progenitor proliferation during postnatal growth and repair[J]. Stem Cells, 2013, 31(8):1597-1610.
[58] MOZZETTA C, CONSALVI S, SACCONE V, et al. Selective control of Pax7 expression by TNF-activated p38α/polycomb repressive complex 2(PRC2) signaling during muscle satellite cell differentiation[J]. Cell Cycle, 2011, 10(2):191-198.
[59] JUAN A H, DERFOUL A, FENG X S, et al. Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells[J]. Genes Dev, 2011, 25(8):789-794.
[60] GILLESPIE M A, LE GRAND F, SCIM A, et al. p38-γ-dependent gene silencing restricts entry into the myogenic differentiation program[J]. J Cell Biol, 2009, 187(7):991-1005.
[61] THOMAS S J, SNOWDEN J A, ZEIDLER M P, et al. The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours[J]. Br J Cancer, 2015, 113(3):365-371.
[62] TRENERRY M K, GATTA P A D, CAMERON-SMITH D. JAK/STAT signaling and human in vitro myogenesis[J]. BMC Physiol, 2011, 11(1):6.
[63] PRICE F D, VON MALTZAHN J, BENTZINGER C F, et al. Corrigendum:inhibition of JAK-STAT signaling stimulates adult satellite cell function[J]. Nat Med, 2014, 20(10):1174-1181.
[64] TIERNEY M T, AYDOGDU T, SALA D, et al. STAT3 signaling controls satellite cell expansion and skeletal muscle repair[J]. Nat Med, 2014, 20(10):1182-1186.
[65] ZHU H, XIAO F, WANG G, et al. STAT3 regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration[J]. Cell Rep, 2016, 16(8):2102-2115.
[66] SCHWÖRER S, BECKER F, FELLER C, et al. Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals[J]. Nature, 2016, 540(7633):428-432.
[67] LEPPER C, PARTRIDGE T A, FAN C M. An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration[J]. Development, 2011, 138(17):3639-3646.

The Role of Key Signaling Pathways in the Proliferation and Differentiation of Skeletal Muscle Satellite Cells

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