脉冲微波辐照对实验动物心脏损伤的病理学研究

畜牧兽医学报 ›› 2006, Vol. 37 ›› Issue (1): 56-60.

脉冲微波辐照对实验动物心脏损伤的病理学研究

邓桦;王德文;彭瑞云;王水明;高亚兵;陈浩宇;马春全;杨鸿

1．佛山科学技术学院生命科学学院，佛山 528231；2．军事医学科学院放射医学研究所，北京100850

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-01-25 发布日期:2006-01-25

Pathologic Studies on Heart Scathe Effect of Experimental Animals Irradiated by Pulse Microwave

DENG Hua;WANG De-wen; PENG Rui-yun;WANG Shui-ming;GAO Ya-bing;CHEN Hao-yu;MA Chun-quan; YANG Hong

1. College of Life Science, Foshan University, Foshan 528231,China;2. Institute of Radiation Medicine, Academy of Military Medical Sciences，Beijing 100850,China

Received:1900-01-01 Revised:1900-01-01 Online:2006-01-25 Published:2006-01-25

摘要/Abstract

摘要： 30只犬，180只大鼠，各随机分为6组，分别以5个功率密度（从1.004 mW/cm²至0.974 kW/cm²）脉冲微波辐照，在辐照后即刻（0 h）至12个月的不同时相点，分别检测其体温、心率、心电图、心肌酶谱等指标，以研究心脏功能的变化；分别取左右房室肌（大鼠取全心）、窦房结、血管等作石蜡切片，并HE、Pollak、PTAH染色，以研究其病理组织学变化；取大鼠心室肌作超薄切片，电镜观测其超微结构的改变。结果发现，辐照后实验动物体温、心率未见明显变化；心电图波形异常，出现以S.T段压低和传导阻滞为主的变化；心肌酶谱出现以活性降低为主的紊乱性变化；辐照可对心肌纤维、窦房结、Purkinje细胞和血管壁等组织结构（包括超微结构）造成损伤。损伤累及全心，并以传导纤维的损伤更为严重。试验结果表明，高功率的脉冲微波可对实验动物心脏功能和结构造成明显损伤，心脏结构损伤和功能障碍均表现速发性、持续性和可缓慢恢复性的特点，损伤在一定范围内呈现剂量效应关系。

关键词: 微波, 心脏, 心肌酶谱, 心电图, 病理组织学, 超微结构

Abstract: 30 dogs and 180 rats were divided into 6 groups randomly and respectively, then irradiated by pulse microwave with 5 different power densities ranged from 1.004 mW/cm² to 0.974 kW/cm² in different group. 12 months after irradiation, animal temperature, heart rate, electrocardiogram and serum myocardial enzyme spectrum were tested to study the changes of heart function，and the pathologic histological changes of myocardium were observed with paraffin slice dyed by HE,Pollak and PTAH respectively, and ultrastructure changes of rat myocardium were examined by electron microscope. The results showed that irradiation influenced the heart functions and damaged myocardial tissue structure although animal temperature and heart rate showed unapparent changes. Cardiogram showed that S-T wave lower and conduction retardation, and serum myocardial enzyme spectrum was disorder significantly stand by decreased activity. Irradiation by pulse microwave can injure structure including ultrastructure of myocardial cells, sinus, Purkinje cells and wall of blood vessels. Damage occured in whole heart and was severer in conduction system. These results indicated that heart is one of the susceptive organs exposed to electromagnetic fields. High power pulse microwave can induce morphological and functional injury of the heart and the related systems. The injuries showed the characteristics of acute, durative and repairable, and the damage degrees may correlate to irradiation dosage in a certain extent.

Key words: microwave, heart, myocardial enzyme spectrum, electrocardiogram, pathologic histology, ultrastructure

邓桦;王德文;彭瑞云;王水明;高亚兵;陈浩宇;马春全;杨鸿. 脉冲微波辐照对实验动物心脏损伤的病理学研究[J]. 畜牧兽医学报, 2006, 37(1): 56-60.

DENG Hua;WANG De-wen;PENG Rui-yun;WANG Shui-ming;GAO Ya-bing;CHEN Hao-yu;MA Chun-quan;YANG Hong. Pathologic Studies on Heart Scathe Effect of Experimental Animals Irradiated by Pulse Microwave[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2006, 37(1): 56-60.

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