支原体分泌蛋白研究进展

doi:10.11843/j.issn.0366-6964.2017.09.002

摘要/Abstract

摘要：

支原体是人和动物的重要病原体，因缺乏特效药物和疫苗用于治疗和预防，常造成很大损失。支原体致病与免疫机制不清是阻碍防治手段研发的重要原因。分泌蛋白直接参与病原体与宿主的交流，是病原体发挥致病和免疫作用的重要组分，可望作为药物和疫苗的潜在靶标。然而支原体分泌蛋白研究尚处于初级阶段，已鉴定的支原体分泌蛋白很少，其在致病与免疫中的作用有待研究。笔者介绍了已发现的支原体分泌蛋白、分泌方式以及其研究方法，以期为支原体分泌蛋白相关研究提供参考。

关键词: 支原体, 分泌蛋白, 靶标, 疫苗, 致病性, 免疫

Abstract:

Mycoplasma is a critical pathogen of humans and animals. Due to lacking of highly effective drugs and vaccines, these diseases cause serious economic losses. The unknown pathogenesis and immunologic response restrict the development of novel drugs and vaccines. Secretory proteins are involved in direct communication between pathogens and hosts and usually considered as the key factors of virulence and immunity. Therefore they are potential targets of novel drugs and vaccines. But the study of secretory proteins of Mycoplasma has just started and only a few of Mycoplasma secretory proteins have been identified. In addition, the functions of secretory proteins in pathogenesis and immunity are mostly unknown. This paper reviewed the identified secretory proteins of Mycoplasma, their secretion pattern, and the methods used in related research, in order to provide some support to future study of Mycoplasma secretory proteins.

Key words: Mycoplasma, secretory protein, target, vaccine, pathogenesis, immunity

中图分类号:

S852.62

胡古月, 赵刚, 陈颖钰, 郭爱珍. 支原体分泌蛋白研究进展[J]. 畜牧兽医学报, 2017, 48(9): 1572-1578.

HU Gu-yue, ZHAO Gang, CHEN Ying-yu, GUO Ai-zhen. Progress on Secretory Proteins of Mycoplasma[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(9): 1572-1578.

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