扁虫中Wnt信号通路的作用

doi:10.11843/j.issn.0366-6964.2017.02.003

摘要/Abstract

摘要：

高度保守的Wnt信号通路调控动物的生长发育、疾病、衰老和死亡等许多生命过程。笔者概述了扁虫（涡虫、绦虫和吸虫）中Wnt信号通路各成分的作用。涡虫中Wnt信号通路能准确指导再生，调节前后（AP）轴形成，维持肌肉细胞和干细胞中沿着AP轴的基因梯度表达，绦虫中Wnt信号通路参与节片的发育，在吸虫中学者们对wnt1、wnt2、wnt4和wnt5基因的功能进行过研究。最后浅谈目前扁虫中Wnt信号通路存在的问题及展望。

关键词: Wnt信号通路, 涡虫, 吸虫, 绦虫

Abstract:

High conserved Wnt signal transduction pathway regulate multiple aspects of animal development, including growth and development, disease, aging, death etc. In this review, we summarize the role of Wnt signaling pathway in flatworm (planarian, tapeworm and trematode). Wnt signaling pathway accurately guide regeneration, regulate antero-posterior (AP) axis patterning and maintain genes gradient expression along AP axis in muscle cells and stem cells in planarian. Wnt signaling pathway regulate the development of proglottid in tapeworm, academics studied the function of wnt1, wnt2, wnt4 and wnt5 genes in the trematode. There are still many questions to be settled and prospects in Wnt signaling pathway in flatworms.

Key words: Wnt signaling pathway, planarian, trematode, tapeworm

中图分类号:

S852.73

王智欣,张艳艳,卢平萍,马勋,王正荣, 薄新文. 扁虫中Wnt信号通路的作用[J]. 畜牧兽医学报, 2017, 48(2): 207-213.

WANG Zhi-xin, ZHANG Yan-yan， LU Ping-ping, MA Xun, WANG Zheng-rong, BO Xin-wen . The Role of Wnt Signaling Pathway in the Flatworm[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(2): 207-213.

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