非洲猪瘟疫苗研究进展

doi:10.11843/j.issn.0366-6964.2016.01.002

摘要/Abstract

摘要：

非洲猪瘟（ASF）是由非洲猪瘟病毒引起的、以软蜱为传播媒介的猪的急性、热性、高度接触性传染病。该病毒主要在网状内皮细胞和单核巨噬细胞中复制，造成细胞凋亡，严重影响宿主的免疫系统。该病虽最早见报于1921年，但由于病毒基因组大，基因型多且非常容易变异等客观原因，造成至今无有效的疫苗面世。国外ASF疫苗研发一直在开拓前行，而国内大多数文献只进行了简单的描述，没有全面展示ASF疫苗的研究进展，为此作者就ASF疫苗的相关研究进展进行综述，以期为我国ASF的疫苗研究提供参考。

关键词: 非洲猪瘟, 细胞免疫, 疫苗

Abstract:

African swine fever（ASF） is an acute，febrile，highly contagious，tick borne disease caused by African swine fever virus.The virus mainly replicate in the reticuloendothelial cells and mononuclear macrophage，resulting in cell apoptosis and causing serious impact on the immune system of the host.Even though the disease was first described in 1921，there is still no efficient vaccine available in the market because of the big virus genome，multi genotype and easily mutation.Even so，foreign scientists keep researching on the development of ASF vaccine.Although there are Chinese articles on ASF had been published，most of these articles provided brief introductions of the disease without fully discussed the development associated with ASF vaccine.Here，in order to provide reference to the research of ASF vaccine，we reviewed the current research progress of ASF vaccine.

Key words: African swine fever, cellular immunity, vaccine

中图分类号:

S858.285.3

戈胜强，吴晓东，张志诚，张永强，赵永刚，王志亮. 非洲猪瘟疫苗研究进展[J]. 畜牧兽医学报, 2016, 47(1): 10-15.

GE Sheng-qiang，WU Xiao-dong，ZHANG Zhi-cheng，ZHANG Yong-qiang，ZHAO Yong-gang，WANG Zhi-liang. Progress in Development of African Swine Fever Vaccine[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(1): 10-15.

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