禽类干扰素受体介导的抗病毒免疫机制研究进展

doi:10.11843/j.issn.0366-6964.2015.08.001

畜牧兽医学报 ›› 2015, Vol. 46 ›› Issue (8): 1273-1280.doi: 10.11843/j.issn.0366-6964.2015.08.001

禽类干扰素受体介导的抗病毒免疫机制研究进展

周浩¹，陈舜^1，2，3*，汪铭书^1，2，3，程安春^1，2，3

（1.四川农业大学动物医学院预防兽医研究所，成都 611130；2.四川农业大学动物医学院禽病防治与研究中心，雅安 625014；3.四川农业大学动物医学院四川省动物疾病与人类健康研究重点实验室，成都 611130）

收稿日期:2014-10-30 出版日期:2015-08-23 发布日期:2015-08-18
通讯作者: 陈舜，女，博士，副研究员，主要从事禽类分子免疫学研究，E-mail：sophia_cs@163.com
作者简介:周浩(1991-)，男，四川新都人，硕士，主要从事分子免疫学研究，E-mail：1913720425@qq.com
基金资助:
国家自然科学基金（31201891）；四川省科技厅青年基金(2012JQ0040)；四川省教育厅重点项目(12ZA107）；教育部高等学校博士学科点专项科研基金(20125103120012)；水禽疫病防控四川省青年科技创新研究团队(2013TD0015)

The Research Progress of Interferon Receptors Mediated Antiviral Immune Mechanism in Avian

ZHOU Hao¹，CHEN Shun^1，2，3* ，WANG Ming-shu^1，2，3，CHENG An-chun^1，2，3

(1.Institute of Preventive Veterinary Medicine，Sichuan Agricultural University，Chengdu 611130，China；2.Avian Disease Research Center，College of Veterinary Medicine of Sichuan Agricultural University，Ya’an 625014，China；3.Key Laboratory of Animal Disease and Human Health of Sichuan Province，Sichuan Agricultural University，Chengdu 611130，China)

Received:2014-10-30 Online:2015-08-23 Published:2015-08-18

摘要/Abstract

摘要：

干扰素受体作为一种“分子开关”，参与调控宿主抗病毒免疫状态和细胞免疫因子的表达水平。作为抗病毒信号传导中的重要枢纽，干扰素受体表达水平的高低直接影响着机体抗病毒免疫反应状态。干扰素受体通过介导宿主抵抗外来病原体的信号级联放大效应来增强机体的抗病毒免疫状态。该正反馈调控机制是抗病毒感染中最重要的免疫扩大反应，也是宿主抵御病毒入侵和增殖的核心反应。禽类干扰素受体研究尚处于起步阶段，本文就干扰素受体的结构和分类，抗病毒效应蛋白质，以及禽类干扰素受体介导的抗病毒免疫机制的最新研究进展作一综述。

关键词: 禽类, 干扰素受体, 抗病毒免疫, 正反馈调节

Abstract:

Interferon receptor is a key molecular switch in regulation of host antiviral immune state and expression level of cellular immune cytokines.As an important hub in antiviral signal transduction，the expression level of interferon receptor directly affects the antiviral immune response system in host.To enhance the antiviral immune response of host against the foreign pathogens，the effect of interferon antiviral signaling cascade will be magnified through interferon receptor upon infection.This positive feedback mechanism is the most important immune amplification effect during antiviral immune response，which is also the core response of host to defend viral invasion and proliferation.Research of avian interferon receptors has still been in its infancy，in this paper，a summary has been conducted on the latest research advance in structure and classification of interferon receptor，downstream antiviral proteins，as well as avian interferon receptor-mediated antiviral immune mechanisms.

Key words: avian, interferon receptors, antiviral immune, positive-feedback regulation

中图分类号:

S852.4

周浩，陈舜，汪铭书，程安春. 禽类干扰素受体介导的抗病毒免疫机制研究进展[J]. 畜牧兽医学报, 2015, 46(8): 1273-1280.

ZHOU Hao，CHEN Shun，WANG Ming-shu，CHENG An-chun. The Research Progress of Interferon Receptors Mediated Antiviral Immune Mechanism in Avian[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(8): 1273-1280.

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禽类干扰素受体介导的抗病毒免疫机制研究进展

The Research Progress of Interferon Receptors Mediated Antiviral Immune Mechanism in Avian

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