核不均一核糖核蛋白与病毒复制

doi:10.11843/j.issn.0366-6964.2015.06.002

摘要/Abstract

摘要：

核不均一核糖核蛋白（hnRNPs）是一类高度保守的RNA结合蛋白，广泛存在于动物的各种组织和细胞中，其主要生理功能是参与细胞中mRNA前体的剪接、mRNA的转运、mRNA的稳定性以及转录的调控。近年来的研究发现，hnRNPs可以通过与病毒核酸、病毒蛋白质结合，调控宿主细胞凋亡等机制影响病毒的复制过程。作者对hnRNPs与病毒复制关系的研究进展做一综述，以期为病毒与机体互作的研究提供参考。

关键词: 核不均一核糖核蛋白, 病毒, 复制, 机制

Abstract:

Heterogeneous nuclear ribonucleoproteins (hnRNPs) is a family of highly conserved RNA-binding proteins，which widely exist in most kinds of tissues and cells.HnRNPs primarily participate in pre-mRNA slicing，mRNA transport，mRNA stability and post-transcriptional regulation in physiological condition.For the past few years，studies have found that hnRNPs could affect viral replication through multiple mechanisms，including binding with viral nuclei acid or viral protein，and regulating apoptosis of host cells.This paper reviews the progress in the study of the relation between heterogeneous nuclear ribonucleoprotein and virus replication.

Key words: heterogeneous nuclear ribonucleoprotein, virus, replication, mechanism

中图分类号:

S852.65

冯晓辉，汤承，朱鑫，岳华. 核不均一核糖核蛋白与病毒复制[J]. 畜牧兽医学报, 2015, 46(6): 882-888.

FENG Xiao-hui，TANG Cheng，ZHU Xin，YUE Hua. Heterogeneous Nuclear Ribonucleoprotein and Virus Replication[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(6): 882-888.

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