关键词: 牛病毒性腹泻病毒, 病毒复制, 宿主细胞, 相互作用

Abstract: Bovine viral diarrhea virus (BVDV) is recognized as one of the important pathogens of ruminant and swine. BVDV causes a series of clinical symptoms of persistent infection, immunosuppression, reproductive disorders and acute or chronic mucosal disease (MD). The disease impacts the economic development of cattle industry. It is difficult to treat and eradicate the disease from cattle because of the complex pathogenesis. With the development of molecular virology of classical swine fever virus and other members of the Flaviviridae, some achievements have been obtained about the research on BVDV, particularly at the cellular and molecular levels. In this paper, the pathogenesis and persistent infection of BVDV are explained, through review the mechanism of BVDV invasion cell, replication and interaction with host cell. It gives some new ideas for vaccine research and control strategy of bovine viral diarrhea (BVD).

Key words: bovine viral diarrhea virus, virus replication, host cell, interaction